Association of Viruses in the Development of Cardiovascular Diseases

Author(s): Bisma Rauff*, Arif Malik, Yasir A. Bhatti, Shafiq A. Chudhary, Kaneez Fatima, Shafquat Rafiq, Aisha Tahir, Sumaira Sharif, Ishtiaq Qadri

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 37 , 2021

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Cardiovascular diseases (CVD), primarily inflammatory cardiomyopathy, are characterized by the infiltration of inflammatory cells into the myocardium. It has a relatively high risk of deteriorating heart function and has heterogeneous etiologies. Inflammatory cardiomyopathy is mainly mediated by viral infections but can also be mediated by protozoa, fungal or bacterial infections. Besides that, there are a wide variety of drugs, toxic substances, and systemic immune-mediated diseases that result in the development of cardiovascular diseases (CVDs). Despite broad research, inflammatory cardiomyopathy has a poor prognosis. The roles of the pathogens, host genomic counterparts and environmental triggers in the progression of disease are still under consideration, including the role of some viruses as active inducers and others as bystanders. In this review article, we review the available evidence on the types, pathogenesis and treatment of myocarditis, inflammatory cardiomyopathy, and atherosclerosis with a particular focus on virus-associated cardiac diseases.

Keywords: COVID-19, cardiovirus, echovirus, coxsackievirus, cytomegalovirus, HSV-1 and 2, parvovirus B19, hepatitis viruses, influenza viruses.

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Article Details

Year: 2021
Published on: 25 April, 2021
Page: [3913 - 3923]
Pages: 11
DOI: 10.2174/1381612827666210426094502
Price: $65

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PDF: 132