Five- and six-membered N-heterocyclic compounds play an important role in medicinal
chemistry and the development of new drugs. There is a constant demand for the development of novel
biologically potent compounds, and there is also an increasing pressure to develop alternative and
more sustainable synthetic methodologies following the Green Chemistry principles. Thus, the present
review aims to compile the latest progress in the use of ultrasound irradiation in water conditions
to mediate the synthesis of five- and six-membered N-heterocyclic compounds in an environmentally
Keywords: N-heterocycles, green chemistry, anti-cancer, ultrasound, sonochemistry, organic synthesis, MCR.
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