Cyclodextrin based nanosponges are the designed nanocarriers for the projected delivery
of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a
three-dimensional, mesh-like network. Their functional characteristics can be fabricated by using
different crosslinkers or their different rations with polymer. They can encapsulate various hydrophilic,
lipophilic, small-sized or large-sized drug molecules. They offer formulation flexibility
and are primarily used for solubility, bioavailability and stability enhancement purposes. This system
is also pliable for co-delivery of pharmaceutical entities, improving therapeutic efficacy and patient
compliance. If the surface of nanosponge is coupled with an appropriate ligand, even a target
specific drug delivery can be achieved. It has a variety of applications in the field of pharmacy for
the delivery of tricky drug molecules, proteins, enzymes, natural moieties and gaseous compounds.
The list of its applications further widens with the development of nanodiagnostics, nanosensors,
biomimetics and scaffolds based on nanosponges. The sudden explosion of research in this working
area signifies cyclodextrin nanosponge based products in the market soon.