Login Register Cart 0
Generic placeholder image

Pharmaceutical Nanotechnology

Editor-in-Chief

ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Mini-Review Article

Self-nanoemulsifying Drug Delivery System: A Versatile Carrier for Lipophilic Drugs

Author(s): Dilpreet Singh*

Volume 9, Issue 3, 2021

Published on: 22 April, 2021

Page: [166 - 176] Pages: 11

DOI: 10.2174/2211738509666210422124023

Price: $65

Abstract

Background: Lipid-based systems such as self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions and offer many useful drug delivery opportunities. In the modern drug discovery era, there is a constant increase in the number of poorly soluble new chemical entities that suffer from poor and erratic bioavailability problems. The oral route possesses some major disadvantages, such as lack of constant drug levels in plasma, firstpass metabolism, which results in poor bioavailability. To address these problems, various lipidbased therapeutic systems are available from which self-enanoemulsifying systems have the potential to increase the bioavailability of poorly soluble drugs.

Methods: SNEDDS is the isotropic mixture of oils, surfactant, and co-surfactant having droplet size in the range of 100-200 nm, which spontaneously emulsifies when it contacts with aqueous media in gastrointestinal (G.I) fluid. Various preparative methods are available for SNEDDS, such as high-pressure homogenizer, microfluidization, sonication, phase inversion, and shear state methods. These methods show favorable benefits in drug delivery. Self-nanoemulsifying drug delivery system possesses some disadvantages like precipitation of drug in G.I fluid or possible drug leaving in the capsule dosage form due to incompatibility issues, which can be overcome by more advanced techniques like supersaturated SNEDDS containing a precipitation inhibitor or Solid SNEDDS. These areformulated either through spray drying or using a solid carrier.

Conclusion: The lipid-based nanocarrier (SNEDDS) plays a significant role in drug delivery to overcome the poor solubility and oral bioavailability. This review highlights the elaborative aspects of the diverse advantages of SNEDDS based formulations.

Keywords: Bioavailability, lipid-based systems, self-nanoemulsion, precipitation inhibitor, phytoconstituents, aqueous solubility.

« Previous Next »
[1]
Katyayani T, Navatha A, Ramya G, Reddy S. Review on self- nano emulsifying drug delivery system. Int J Res Pharm Sci 2011; 2(3): 382-92.
[2]
Vishvajit A. Kamble, Deepali M, Jagdale l, Vilasrao J. Self nano emulsifying drug delivery system. Int J Pharm Bio Sci 2010; 1(2): 2-3.
[3]
Akula S, Gurram AK, Devireddy SR. Self nano emulsifying drug delivery system: an attractive strategy for the enhanced therapeutic profile. Int Scholarly Res Notices 2014; 964051: 1-11.
[4]
Meghani N, Suares D. Self nano emulsifying drug delivery system (SNEDDS): a promising tool to improve bioavailability. J Pharm Phyto Ther 2017; 2(1): 17-21.
[5]
Jaiswal P, Aggarwal G, Harikumar SL, Kaur A. Bioavailability enhancement of poorly soluble drugs by SNEDDS: a review. J Drug Deliv Ther 2013; 3(1): 98-109.
[http://dx.doi.org/10.22270/jddt.v3i1.360]
[6]
Shukla P, Prajapati SK, Sharma UK, Shipra S, Ali A. A review on self-micro emulsifying drug delivery system: An approach to enhance the oral bioavailability of poorly soluble drugs. Int Res J Pharm 2012; 3(9): 1-6.
[7]
Khamkar GS. Self nano emulsifying drug delivery system (SMEDD) O/W Microemulsion for BCS class II Drugs: an approach to enhance oral bioavailability. Int J Pharm Pharm Sci 2011; 2(3): 1-3.
[8]
Pandya BD, Shah SH, Shah N. Bioavailability enhancement of poorly soluble drugs by Self-micro emulsifying drug delivery system (SNEDDS): a review. J Pharm Sci Bio Sci Res 2015; 5(2): 187-96.
[9]
Singh D, Tiwary AK, Bedi N. Self-microemulsifying drug delivery system for problematic molecules: An update. Recent Pat Nanotechnol 2019; 13(2): 92-113.
[http://dx.doi.org/10.2174/1872210513666190619102521] [PMID: 31215381]
[10]
Sarbal K, Pawar YB, Bansal AK. Self-Emulsifying drug delivery systems: a strategy to improve oral bioavailability. CRIPS 2015; 11: 42-9.
[11]
Yeole S, Pimple SS, Gale GS. Gonarkar, Ashwani G, Nigde AT. A review: self micro emulsifying drug delivery system (SNEDDS). Ind Am J Pharm Res 2013; 3(4): 3031-43.
[12]
Reddy S, Katyayani T, Navatha A, Ramya G. Review on Self nano emulsifying drug delivery systems. Int J Pharma Sci 2011; 2(3): 382-92.
[13]
Woo JS, Song YK, Hong JY, Lim SJ, Kim CK. Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers. Eur J Pharm Sci 2008; 33(2): 159-65.
[http://dx.doi.org/10.1016/j.ejps.2007.11.001] [PMID: 18178070]
[14]
Taha E, Ghorab D, Zaghloul AA. Bioavailability assessment of Vitamin A Self-nano emulsified drug delivery system in rats. Med Princ Pract 2007; 9: 16-35.
[15]
Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res 1995; 12(11): 1561-72.
[http://dx.doi.org/10.1023/A:1016268311867] [PMID: 8592652]
[16]
Dokania S, Joshi AK. Self-micro emulsifying drug delivery system (SNEDDS)-Challenges and Road Ahead. Drug Deliv Early (Bergh) 2015; 22(6): 675-90.: 1-690.
[17]
Chen ML. Lipid excipients and delivery systems for pharmaceutical development: a regulatory perspective. Adv Drug Deliv Rev 2008; 60(6): 768-77.
[http://dx.doi.org/10.1016/j.addr.2007.09.010] [PMID: 18077051]
[18]
Khan AW, Kotta S, Ansari SH, Sharma RK, Ali J. Potential and challenges in Self-nano emulsifying drug delivery system. Expert Opin Drug Deliv 2012; 9(10): 1-13.
[19]
Gade AV, Salunkhe KS, Chaudhari SR, Gadge PB. Review on Self nano emulsifying drug delivery system. Am J Pharm Tech Res 2015; 5(1): 50-66.
[20]
Date AA, Desai N, Dixit R, Nagarsenker M. Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine (Lond) 2010; 5(10): 1595-616.
[http://dx.doi.org/10.2217/nnm.10.126] [PMID: 21143036]
[21]
Strickley RG. Solubilizing excipients in oral and injectable formulations. Pharm Res 2004; 21(2): 201-30.
[http://dx.doi.org/10.1023/B:PHAM.0000016235.32639.23] [PMID: 15032302]
[22]
Rege BD, Kao JP, Polli JE. Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur J Pharm Sci 2002; 16(4-5): 237-46.
[http://dx.doi.org/10.1016/S0928-0987(02)00055-6] [PMID: 12208453]
[23]
Hugger ED, Novak BL, Burton PS, Audus KL, Borchardt RT. A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. J Pharm Sci 2002; 91(9): 1991-2002.
[http://dx.doi.org/10.1002/jps.10176] [PMID: 12210046]
[24]
ten Tije AJ, Verweij J, Loos WJ, Sparreboom A. Pharmacological effects of formulation vehicles: implications for cancer chemotherapy. Clin Pharmacokinet 2003; 42(7): 665-85.
[http://dx.doi.org/10.2165/00003088-200342070-00005] [PMID: 12844327]
[25]
Müllertz A, Ogbonna A, Ren S, Rades T. New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs. J Pharm Pharmacol 2010; 62(11): 1622-36.
[http://dx.doi.org/10.1111/j.2042-7158.2010.01107.x] [PMID: 21039546]
[26]
Patel MJ, Patel SS, Patel NM, Patel MM. A self-nano emulsifying drug delivery system (SNEDDS). Int J Pharm Sci Rev Res 2010; 4(3): 29-35.
[27]
Schulman JH, Stoeckenius W, Prince LM. Mechanism of formation and structure of microemulsions by electron microscopy. J Phys Chem 1959; 63(10): 1677-80.
[http://dx.doi.org/10.1021/j150580a027]
[28]
Cherniakov I, Domb AJ, Hoffman A. Self-nano-emulsifying drug delivery systems: an update of the biopharmaceutical aspects. Expert Opin Drug Deliv 2015; 12(7): 1121-33.
[http://dx.doi.org/10.1517/17425247.2015.999038] [PMID: 25556987]
[29]
Jain NK. Introduction to novel drug delivery system. 4th ed. India: Vallabh Publications 2010; pp. 210-21.
[30]
Vyas SP, Khar RK. Targeted and controlled drug delivery. 1st ed. CBZ publishers 2007; pp. 280-300.
[31]
Ghosh PK, Murthy RS. Microemulsions: a potential drug delivery system. Curr Drug Deliv 2006; 3(2): 167-80.
[http://dx.doi.org/10.2174/156720106776359168] [PMID: 16611003]
[32]
Lawrence MJ, Rees GD. Microemulsion based media as novel drug delivery. Adv Drug Deliv 2000; 45(1): 89-121.
[http://dx.doi.org/10.1016/S0169-409X(00)00103-4]
[33]
Cui S, Zhao C, Chen D, He Z. Self-microemulsifying drug delivery systems (SMEDDS) for improving in vitro dissolution and oral absorption of Pueraria lobata isoflavone. Drug Dev Ind Pharm 2005; 31(4-5): 349-56.
[http://dx.doi.org/10.1081/DDC-54309] [PMID: 16093200]
[34]
Date AA, Nagarsenker MS. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int J Pharm 2007; 329(1-2): 166-72.
[http://dx.doi.org/10.1016/j.ijpharm.2006.08.038] [PMID: 17010543]
[35]
Yeole M, Dhole S, Kulkarni N. Development and evaluation of poorly aqueous soluble drug Racecadotril by solid self-micro emulsifying drug delivery approach. Int Res J Pharm 2014; 5(7): 565-75.
[http://dx.doi.org/10.7897/2230-8407.0507115]
[36]
Mekjaruskul C, Yang YT, Leed MG, Sadgrove MP, Jay M, Sripanidkulchai B. Novel formulation strategies for enhancing oral delivery of methoxyflavones in Kaempferia parviflora by SMEDDS or complexation with 2-hydroxypropyl-β-cyclodextrin. Int J Pharm 2013; 445(1-2): 1-11.
[http://dx.doi.org/10.1016/j.ijpharm.2013.01.052] [PMID: 23376503]
[37]
Mountfield RJ, Senepin S, Schleimer M, Walter I, Bittner B. Potential inhibitory effects of formulation ingredients on intestinal cytochrome P450. Int J Pharm 2000; 211(1-2): 89-92.
[http://dx.doi.org/10.1016/S0378-5173(00)00586-X] [PMID: 11137342]
[38]
Subramanian R, Wasan KM. Effect of lipid excipients on in vitro pancreatic lipase activity. Drug Dev Ind Pharm 2003; 29(8): 885-90.
[http://dx.doi.org/10.1081/DDC-120024184] [PMID: 14570309]
[39]
Ren S, Park MJ, Kim A, Lee BJ. In vitro metabolic stability of moisture-sensitive rabeprazole in human liver microsomes and its modulation by pharmaceutical excipients. Arch Pharm Res 2008; 31(3): 406-13.
[http://dx.doi.org/10.1007/s12272-001-1171-z] [PMID: 18409057]
[40]
Nawale RB, Mehta BN. Glibenclamide loaded self-micro emulsifying drug delivery system (SNEDDS); Development and optimization. Int J Pharm Sci 2013; 5: 325-30.
[41]
Shen H, Zhong M. Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. J Pharm Pharmacol 2006; 58(9): 1183-91.
[http://dx.doi.org/10.1211/jpp.58.9.0004] [PMID: 16945176]
[42]
Guo F, Zhong H, He J, et al. Self-microemulsifying drug delivery system for improved oral bioavailability of dipyridamole: preparation and evaluation. Arch Pharm Res 2011; 34(7): 1113-23.
[http://dx.doi.org/10.1007/s12272-011-0709-8] [PMID: 21811918]
[43]
Young-Dae Cho, Young joom Park. In vitro and in vivo evaluation of a self-micro emulsifying drug delivery system for the poorly soluble drug fenofibrate. Arch Pharm Res 2018; 37: 193-203.
[44]
Jawad A, Intan FS, Jiyauddin K, Budiasih S, Samer AD. Formulation and development of self nano emulsifying drug delivery system (SNEDDS) of Flurbiprofen. World J Pharm Res 2014; 3(7): 105-24.
[45]
Aggarwal AG, Kumar A, Gide PS. Self emulsifying drug delivery system for enhanced solubility and dissolution of Glipizide. Colloids Surf Biointerf 2019; 126: 553-60.
[http://dx.doi.org/10.1016/j.colsurfb.2014.11.022]
[46]
Borhade V, Nair H, Hegde D. Design and evaluation of self-microemulsifying drug delivery system (SMEDDS) of tacrolimus. AAPS PharmSciTech 2008; 9(1): 13-21.
[http://dx.doi.org/10.1208/s12249-007-9014-8] [PMID: 18446456]
[47]
Qureshi MJ, Mallikarjun C, Kian WG. Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SNEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets: a study in diet-induced hyperlipidemic rabbits. Asian J Pharm Sci 2015; 10: 40-56.
[48]
Puttachari S, Kalyane NV, Gupta S. Design and evaluation of self nano emulsifying drug delivery system of Acyclovir. Int J Pharm Pharm Sci 2018; 6(4): 677-81.
[49]
Dixit AR, Rajput SJ, Patel SG. Preparation and bioavailability assessment of SNEDDS containing valsartan. AAPSPharmSciTech 2010; 1-8.
[http://dx.doi.org/10.1208 /s12249-010-9385-0]
[50]
Hyma P, Chandra A, Abbulu K. Formulation and characterization of Telmisartan Self nano emulsifying drug delivery system. Int J Pharm Pharm Sci 2013; 6(1): 120-5.
[51]
Yao J, Wang D, Zhang X, Genthe CB, Zhu P, He L. Development of docetaxel self-micro emulsifying drug delivery system (SNEDDS) for parenteral delivery: preparation, characterization and in vivo evaluation. Asian. J Pharm Sci 2012; 7(4): 18-27.
[52]
Singh AK, Chaurasiya A, Awasthi A, et al. Oral bioavailability enhancement of exemestane from self-microemulsifying drug delivery system (SMEDDS). AAPS PharmSciTech 2009; 10(3): 906-16.
[http://dx.doi.org/10.1208/s12249-009-9281-7] [PMID: 19609837]
[53]
Hintzen F, Perera G, Hauptstein S, Müller C, Laffleur F, Bernkop-Schnürch A. In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin. Int J Pharm 2014; 472(1-2): 20-6.
[http://dx.doi.org/10.1016/j.ijpharm.2014.05.047] [PMID: 24879935]
[54]
Cui J, Yu B, Zhao Y, et al. Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems. Int J Pharm 2009; 371(1-2): 148-55.
[http://dx.doi.org/10.1016/j.ijpharm.2008.12.009] [PMID: 19124065]
[55]
Li Q, Zhai W, Jiang Q, et al. Curcumin-piperine mixtures in self-micro emulsifying drug delivery system for ulcerative colitis. Int J Pharm 2015; 490(1-2): 22-31.
[http://dx.doi.org/10.1016/j.ijpharm.2015.05.008]
[56]
Zhu JX, Tang D, Feng L, et al. Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride. Drug Dev Ind Pharm 2013; 39(3): 499-506.
[http://dx.doi.org/10.3109/03639045.2012.683875] [PMID: 22563917]
[57]
Jong soo-soo, Tae-soo Kim, Jae-Hyun-Park, Sang-cheol chi. Formulation and Biopharmaceutical Evaluation of Silymarin Using SNEDDS. Arch Pharm Res 2007; 30(1): 82-9.
[PMID: 17328246]
[58]
Mandawgade SD, Sharma S, Pathak S, Patravale VB. Development of SMEDDS using natural lipophile: application to β-Artemether delivery. Int J Pharm 2008; 362(1-2): 179-83.
[http://dx.doi.org/10.1016/j.ijpharm.2008.06.021] [PMID: 18652886]
[59]
Liu w, Tian R, Hu W, Jia Y, Jiang H. Preparation and evaluation of self-nano emulsifying drug delivery system of baicalein. Fitoterapia 2012; 83(8): 1532-9.
[http://dx.doi.org/10.1016/j.fitote.2012.08.021] [PMID: 22982454]
[60]
Wang DK, Shi ZH, Liu L, Wang XY, Zhang CX, Zhao P. Development of self-microemulsifying drug delivery systems for oral bioavailability enhancement of alpha-Asarone in beagle dogs. PDA J Pharm Sci Technol 2006; 60(6): 343-9.
[PMID: 17260899]
[61]
Charman SA, Charman WN, Rogge MC, Wisdon TD, Dutko FJ. Self-emulsifying drug delivery systems: formulation and biopharmaceutical evaluation of investigational lipophilic compound. Pharm Res 1992; 12: 1561-72.
[62]
Charman WN, Noguchi T, Stella VJ. An experimental system designed to study the in situ intestinal lymphatic transport of lipophilic drugs in anesthetized rats. Int J Pharm 1986; 33: 155-64.
[http://dx.doi.org/10.1016/0378-5173(86)90049-9]
[63]
Oussoren C, Storm G. Liposomes to target the lymphatics by subcutaneous administration. Adv Drug Deliv Rev 2001; 50(1-2): 143-56.
[http://dx.doi.org/10.1016/S0169-409X(01)00154-5] [PMID: 11489337]
[64]
Oussoren C, Zuidema J, Crommelin DJA, Storm G. Lymphatic uptake and biodistribution of liposomes after subcutaneous injection. II. Influence of liposomal size, lipid compostion and lipid dose. Biochim Biophys Acta 1997; 1328(2): 261-72.
[http://dx.doi.org/10.1016/S0005-2736(97)00122-3] [PMID: 9315622]
[65]
Charman WN, Stella VJ. Estimating the maximal potentials for intestinal lymphatic transport of lipophilic drug molecules. Int J Pharm 1986; 34: 175-8.
[http://dx.doi.org/10.1016/0378-5173(86)90027-X]
[66]
Khoo SM, Porter CJH, Edwards GA, Charman WN. Intestinal lymphatic route is the primary route for halofantrine after postprandial administration. Pharm Sci 1999; 1: S-624.
[67]
Baheti A, Srivastava S, Sahoo D, et al. Development and pharmacokinetic evaluation of industrially viable self-microemulsifying drug delivery systems (SMEDDS) for terbinafine. Curr Drug Deliv 2015; 55: 308-20.
[PMID: 25600982]
[68]
Lo YL, Hsu CY, Huang JD. Comparison of effects of surfactants with other MDR reversing agents on intracellular uptake of epirubicin in Caco-2 cell line. Anticancer Res 1998; 18(4C): 3005-9.
[PMID: 9713500]
[69]
Lo YL. Phospholipids as multidrug resistance modulators of the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats. Biochem Pharmacol 2000; 60(9): 1381-90.
[http://dx.doi.org/10.1016/S0006-2952(00)00451-2] [PMID: 11008132]
[70]
Yamazaki T, Sato Y, Hanai M, et al. Non-ionic detergent Tween 80 modulates VP-16 resistance in classical multidrug resistant K562 cells via enhancement of VP-16 influx. Cancer Lett 2000; 149(1-2): 153-61.
[http://dx.doi.org/10.1016/S0304-3835(99)00355-9] [PMID: 10737719]
[71]
Gao P, Rush BD, Pfund WP, et al. Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability. J Pharm Sci 2003; 92(12): 2386-98.
[http://dx.doi.org/10.1002/jps.10511] [PMID: 14603484]
[72]
Nan Z, Lijun G, Tao W, Dongqin Q. Evaluation of Carbamazepine (CBZ) supersaturate self-micro emulsifying (S-SNEDDS) formulation in vitro and in vivo. Iran J Pharm Res 2012; 11(1): 257-64.
[PMID: 24250448]
[73]
Tang B, Cheng G, Gu JC, Xu CH. Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discov Today. Netherlands: Elsevier 2008; 13: pp. (13-14)606-12.
[http://dx.doi.org/10.1016/j.drudis.2008.04.006] [PMID: 18598917]
[74]
Haritha M, Kumar BP. Formulation and evaluation of Cefixime Dry emulsion. J Chem Pharm Sci 2013; 6(4): 234-8.
[75]
Qi X, Qin J, Ma N, Chou X, Wu Z. Solid self-microemulsifying dispersible tablets of celastrol: formulation development, charaterization and bioavailability evaluation. Int J Pharm 2014; 472(1-2): 40-7.
[http://dx.doi.org/10.1016/j.ijpharm.2014.06.019] [PMID: 24929011]
[76]
Xiongwei HU, Chan L, Ding Xiong C, Jing Z, Zhihong L, Hongtao S. Sirolimus solid self-microemulsifying pellets: formulation development, characterization and bioavailability evaluation. Int J Pharm 2012; 438: 123-33.
[77]
Bhagwat DA, D’souza JI. Development of solid self micro emulsifying drug delivery system with neusilin us2 for enhanced dissolution rate of telmisartan. Int J Drug Dev Res 2012; 4(4): 398-407.
[78]
Kishore RN, Yalavarthi PR, Vadlamudi HC, Vandana KR, Rasheed A. Solid self-micro emulsification of atorvastatin using hydrophilic carriers: a design. Drug Dev Ind Pharm 2014; 24: 1-10.
[79]
Mura P, Valleri M, Cirri M, Mennini N. New solid self-microemulsifying systems to enhance dissolution rate of poorly water soluble drugs. Pharm Dev Technol 2012; 17(3): 277-84.
[http://dx.doi.org/10.3109/10837450.2010.535825] [PMID: 21108583]
[80]
Yi T, Wan J, Xu H, Yang X. A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. Eur J Pharm Biopharm 2008; 70(2): 439-44.
[http://dx.doi.org/10.1016/j.ejpb.2008.05.001] [PMID: 18603415]
[81]
Beg S, Sandhu PS, Batra RS, Khurana RK, Singh B. QbD-based systematic development of novel optimized solid self-nanoemulsifying drug delivery systems (SNEDDS) of lovastatin with enhanced biopharmaceutical performance. Drug Deliv 2015; 22(6): 765-84.
[http://dx.doi.org/10.3109/10717544.2014.900154] [PMID: 24673611]
[82]
Deshmukh A, Kulkarni S. Solid self-microemulsifying drug delivery system of ritonavir. Drug Dev Ind Pharm 2013; 12: 1-11.
[PMID: 23465049]
[83]
Nekkanti V, Karatgi P, Prabhu R, Pillai R. Solid self-microemulsifying formulation for candesartan cilexetil. AAPS PharmSciTech 2010; 11(1): 9-17.
[http://dx.doi.org/10.1208/s12249-009-9347-6] [PMID: 20013081]
[84]
Katja C, Alenka Z, Franc V, Mirjana G. Development of Solid Self-microemulsifying drug delivery system (SNEDDS) for solubility enhancement of naproxen. Drug Dev Ind Pharm 2015; 41(9): 1548-57.
[85]
Legon I, Peternel L, Novak SM, Homar M, Rozman PT, Klancer U. Self-microemulsifying drug delivery system of abiraterone or abiraterone acetate. US Patent WO2014009434A, 2014.
[86]
Jody FMV. Self-microemulsifying drug delivery system of an HIV protease inhibitor. US Patent WO2005063209 A1, 2005.
[87]
Asem L, Sunjia N, Zhang Q, Wang X, Fanjhe M. Preparation of Self-microemulsifying drug delivery system for oral administration or intravenous injection and use thereof National patent CN200910203734, 2011.
[88]
Jie Y. Mitiglinide calcium self-nano emulsifying drug delivery system National patent CN101138549B, 2012.
[89]
Battung F, Hassan E, Sansoe L. Self-micro emulsifying mitotane composition US Patent US8486445B2, 2013.
[90]
Chang HC, Pharma DW, Lee MS, Jo YH. Self-microemulsifying drug delivery system composition containing coenzyme-Q10 and method for preparing the same US Patent WO2009022798A2, 2009.

Rights & Permissions Print Cite
Article Metrics
32
1
© 2024 Bentham Science Publishers | Privacy Policy