The Role of Cholesterol Homeostasis in Diabetic Kidney Disease

Author(s): Xinyun Chen, Qinghua Yin, Liang Ma*, Ping Fu

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 36 , 2021


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Abstract:

Considerable evidence has proved that disturbed cholesterol metabolism played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions were found in intrinsic renal cells of diabetic kidney disease patients and animal models, causing cytotoxicity and affecting renal function. Statins could alleviate cholesterol depositions, podocyte injury, and microalbuminuria of diabetic kidney disease. In this review, we summarized the process of disturbed cholesterol metabolism and discussed how it induced kidney dysfunction in diabetic kidney disease.

Keywords: Cholesterol, diabetic kidney disease, SREBP2, LDLR, ABCA1, ABCG1.

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Article Details

VOLUME: 28
ISSUE: 36
Year: 2021
Published on: 19 April, 2021
Page: [7413 - 7426]
Pages: 14
DOI: 10.2174/0929867328666210419132807
Price: $65

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