Abstract
Considerable evidence has proved that disturbed cholesterol metabolism played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions were found in intrinsic renal cells of diabetic kidney disease patients and animal models, causing cytotoxicity and affecting renal function. Statins could alleviate cholesterol depositions, podocyte injury, and microalbuminuria of diabetic kidney disease. In this review, we summarized the process of disturbed cholesterol metabolism and discussed how it induced kidney dysfunction in diabetic kidney disease.
Keywords: Cholesterol, diabetic kidney disease, SREBP2, LDLR, ABCA1, ABCG1.
Current Medicinal Chemistry
Title:The Role of Cholesterol Homeostasis in Diabetic Kidney Disease
Volume: 28 Issue: 36
Author(s): Xinyun Chen, Qinghua Yin, Liang Ma* Ping Fu
Affiliation:
- Kidney Research Institute, Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041,China
Keywords: Cholesterol, diabetic kidney disease, SREBP2, LDLR, ABCA1, ABCG1.
Abstract: Considerable evidence has proved that disturbed cholesterol metabolism played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions were found in intrinsic renal cells of diabetic kidney disease patients and animal models, causing cytotoxicity and affecting renal function. Statins could alleviate cholesterol depositions, podocyte injury, and microalbuminuria of diabetic kidney disease. In this review, we summarized the process of disturbed cholesterol metabolism and discussed how it induced kidney dysfunction in diabetic kidney disease.
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Cite this article as:
Chen Xinyun , Yin Qinghua , Ma Liang *, Fu Ping , The Role of Cholesterol Homeostasis in Diabetic Kidney Disease, Current Medicinal Chemistry 2021; 28 (36) . https://dx.doi.org/10.2174/0929867328666210419132807
DOI https://dx.doi.org/10.2174/0929867328666210419132807 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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