Abstract
The PdII-mediated cross-coupling of (hetero)arenes with alkenes may be an effective method for the formation of a C–C bond from two C–H bonds. This reaction was discovered by Fujiwara and his co-workers in 1967, which led to a number of reports that we first highlighted in 2011 (review with references till June 2010) and for which we retained the name “Dehydrogenative Heck Reaction” (DHR). The DHR of six-membered heteroarenes has been the subject of intensive research over the last ten years. The present review is limited to these dehydrogenative Heck reactions published since 2010, underlining the diversity of the procedures, mechanisms and intermediates that have been proposed along with some personal comments.
Keywords: Palladium, heteroarene, dehydrogenative Heck reaction, cross-coupling, C–H activation, alkenylation, catalysis.
Current Organic Chemistry
Title:Pd-catalyzed Intermolecular Dehydrogenative Heck Reactions of Six-membered Heteroarenes
Volume: 25 Issue: 18
Author(s): Jean Le Bras and Jacques Muzart*
Affiliation:
- Institut de Chimie Moleculaire de Reims, UMR 7312, CNRS - Université de Reims Champagne-Ardenne, B.P. 1039, 51687 Reims Cedex 2,France
Keywords: Palladium, heteroarene, dehydrogenative Heck reaction, cross-coupling, C–H activation, alkenylation, catalysis.
Abstract: The PdII-mediated cross-coupling of (hetero)arenes with alkenes may be an effective method for the formation of a C–C bond from two C–H bonds. This reaction was discovered by Fujiwara and his co-workers in 1967, which led to a number of reports that we first highlighted in 2011 (review with references till June 2010) and for which we retained the name “Dehydrogenative Heck Reaction” (DHR). The DHR of six-membered heteroarenes has been the subject of intensive research over the last ten years. The present review is limited to these dehydrogenative Heck reactions published since 2010, underlining the diversity of the procedures, mechanisms and intermediates that have been proposed along with some personal comments.
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Cite this article as:
Bras Le Jean and Muzart Jacques *, Pd-catalyzed Intermolecular Dehydrogenative Heck Reactions of Six-membered Heteroarenes, Current Organic Chemistry 2021; 25 (18) . https://dx.doi.org/10.2174/1385272825666210412160959
DOI https://dx.doi.org/10.2174/1385272825666210412160959 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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