Background: Cannabis Sativa seed oil has become more and more popular in cosmetic industry
mainly due to the high content of antioxidants and unsaturated fatty acids that are desirable in
formulations because they prevent moisture loss and reduce the occurrence of dry skin.
Objective: The aim of this study was to determine the effect of Cannabis Sativa seed oil on skin parameters
such as hydration and transepidermal water loss.
Methods: The in vivo tests on volunteers with combination skin were performed by using corneometer
Results: The obtained results proved that Cannabis Sativa seed oil improved skin condition. The transepidermal
water loss decreased because the lipophilic components of the oil formulation tend to form
an occlusive layer on the epidermis surface. The highest increase in skin hydration was observed after
one week of treatment.
Conclusion: These results confirmed that Cannabis Sativa seed oil has strong moisturizing properties
and can be recommended as a natural-based skin conditioning agent.