Background: Colorectal cancer (CRC) is considered one of the most predominant and
deadly cancer globally. Nowadays, the main clinical management for this cancer includes chemotherapy
and surgery; however, these treatments result in the occurrence of drug resistance and
severe side effects, and thus it is a crucial requirement to discover an alternative and potential therapy
for CRC treatment. Numerous therapeutic cancers were initially recognized from natural
metabolites utilized in traditional medicine, and several recent types of research have shown that
many natural products own potential effects against CRC and may assist the action of chemotherapy
for the treatment of CRC. It has been indicated that most patients are well tolerated by natural
compounds without showing any toxicity signs even at high doses. Conventional chemotherapeutics
interaction with natural medicinal compounds presents a new feature in cancer exploration and
treatment. Most of the natural compounds overwhelm malignant cell propagation by apoptosis initiation
of CRC cells and arresting of the cell cycle (especially at G, S, and G2/M phase) that result in
inhibition of tumor growth.
Objective: This mini-review aimed to focus on natural compounds (alkaloids, flavonoids,
polysaccharides, polyphenols, terpenoids, lactones, quinones, etc.) that were identified to have anti-
CRC activity in vitro on CRC cell lines and/or in vivo experiments on animal models.
Conclusion: Most of the studied active natural compounds possess anti-CRC activity via different
mechanisms and pathways in vitro and in vivo that might be used as assistance by clinicians to support
chemotherapy therapeutic strategy and treatment doses for cancer patients.