The Role of ASIC1a in Epilepsy: A Potential Therapeutic Target

Author(s): Yu Cheng, Wuqiong Zhang, Yue Li, Ting Jiang, Buhajar Mamat, Yunhai Zhang, Famin Wang, Hongmei Meng*

Journal Name: Current Neuropharmacology

Volume 19 , Issue 11 , 2021


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Abstract:

Background: Epilepsy represents one of the most common brain diseases among humans. Tissue acidosis is a common phenomenon in epileptogenic foci. Moreover, its role in epileptogenesis remains unclear. Acid-sensing ion channel-1a (ASIC1a) represents a potential way to assess new therapies. ASIC1a, mainly expressed in the mammalian brain, is a type of protein-gated cation channel. It has been shown to play an important role in the pathological mechanism of various diseases, including stroke, epilepsy, and multiple sclerosis.

Methods: Data were collected from Web of Science, Medline, PubMed, through searching for these keywords: "Acid-sensing ion channels 1a" or "ASIC1a" and "epilepsy" or "seizure".

Results: The role of ASIC1a in epilepsy remains controversial; it may represent a promising therapeutic target of epilepsy.

Conclusion: This review is intended to provide an overview of the structure, trafficking, and molecular mechanisms of ASIC1a in order to elucidate the role of ASIC1a in epilepsy further.

Keywords: Acid-sensing ion channels-1a, ASIC1a, epilepsy, sodium channels, synaptic plasticity, neuron.

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Article Details

VOLUME: 19
ISSUE: 11
Year: 2021
Published on: 01 April, 2021
Page: [1855 - 1864]
Pages: 10
DOI: 10.2174/1570159X19666210402102232
Price: $65

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