SARS-CoV-2 Spread Dynamics in Italy: The Calabria Experience

Author(s): Ludovico Abenavoli*, Pietro Cinaglia, Anna Caterina Procopio, Raffaele Serra, Isabella Aquila, Christian Zanza, Yaroslava Longhitano, Marco Artico, Tiziana Larussa, Luigi Boccuto, Pietrantonio Ricci, Francesco Luzza

Journal Name: Reviews on Recent Clinical Trials

Volume 16 , Issue 3 , 2021

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Graphical Abstract:


Introduction: The first case of infection by SARS-CoV-2 (i.e., COVID-19) has been officially recorded by the Italian National Health Service on February 21st, 2020. Lombardy was the first Italian region to be affected by the pandemic. Subsequently, the entire Northern part of Italy recorded a high number of cases, while the South was hit following the migratory waves. On March 8th, the Italian Government has issued a decree that imposed a total lockdown, defining it as a state of isolation and restricting access in Lombardy and the other 14 provinces of Northern Italy.

Methods: We analyzed the virus trend in the period between February 24th and September 8th, 2020, focusing on Calabria, with regards to the following items: new positives, change of total positives, and total cases. Furthermore, we included other information, such as the incubation period, symptom resolution period, quarantine period.

Results: On March 27th, the epidemic curve spiked with 101 new positive cases validating the hypothesis that this abnormal event was related to the displacement of non-residents people, living in the Northern part of Italy, to the home regions in the South. The epidemic curve showed a decreasing trend in the period after lockdown, proving the effectiveness of this measure. From the end of the lockdown May 04th to September 8th, the registered trend was -94.51%. A negative growth rate indicates that the number of new positive cases is lower than the number of healed patients.

Conclusion: This study describes the effectiveness of the Italian Government policy, particularly the role of lockdown, for the containment of SARS-CoV-2 contagion in Calabria, a region with a low SARS-CoV-2 infection rate within the registered period.

Keywords: Epidemiology, public health, Covid-19, contagion, trend, Italy.

Gentile I, Abenavoli L. COVID-19: Perspectives on the potential novel global threat. Rev Recent Clin Trials 2020; 15(2): 84-6.
[] [PMID: 32116200]
Abenavoli L, Cinaglia P, Luzza F, Gentile I, Boccuto L. Epidemiology of coronavirus disease outbreak: The Italian trends. Rev Recent Clin Trials 2020; 15(2): 87-92.
[] [PMID: 32264813]
Armocida B, Formenti B, Ussai S, Palestra F, Missoni E. The Italian health system and the COVID-19 challenge. Lancet Public Health 2020; 5(5): e253.
[] [PMID: 32220653]
Fagiuoli S, Lorini FL, Remuzzi G. Adaptations and lessons in the province of bergamo. N Engl J Med 2020; 382(21): e71.
[] [PMID: 32369276]
Decreto del Presidente del Consiglio dei Ministri 2020. Available online:
Decreto del Presidente del Consiglio dei Ministri 2020. Available online:
Bollettino Regione Calabria 2020. Available online:
Department of Italian Civil Protection. Official statistical data for Covid-19 in Italy Available online:
Lauer SA, Grantz KH, Bi Q, et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: Estimation and application. Ann Intern Med 2020; 172(9): 577-82.
[] [PMID: 32150748]
Chang D, Mo G, Yuan X, et al. Time kinetics of viral clearance and resolution of symptoms in novel coronavirus infection. Am J Respir Crit Care Med 2020; 201(9): 1150-2.
[] [PMID: 32200654]
Nicola M, O’Neill N, Sohrabi C, Khan M, Agha M, Agha R. Evidence based management guideline for the COVID-19 pandemic - Review article. Int J Surg 2020; 77: 206-16.
[] [PMID: 32289472]
Qualls N, Levitt A, Kanade N, et al. Community mitigation guidelines to prevent pandemic influenza - United States, 2017. MMWR Recomm Rep 2017; 66(1): 1-34.
[] [PMID: 28426646]
McAloon C, Collins Á, Hunt K, et al. Incubation period of COVID-19: a rapid systematic review and meta-analysis of observational research. BMJ Open 2020; 10(8): e039652.
[] [PMID: 32801208]
Aquila I, Sacco MA, Ricci C, Gratteri S, Ricci P. Quarantine of the Covid-19 pandemic in suicide: A psychological autopsy. Med Leg J 2020; 88(4): 182-4.
[] [PMID: 32410517]
Aquila I, Ricci P, Bonetta CF, et al. Analysis of the persistence time of the SARS-CoV-2 virus in the cadaver and the risk of passing infection to autopsy staff. Med Leg J 2021; 89(1): 40-53.
[] [PMID: 33475037]
Bettini E, Locci M. SARS-CoV-2 mRNA vaccines: Immunological mechanism and beyond. Vaccines (Basel) 2021; 9(2): 147.
[] [PMID: 33673048]
Krammer F. SARS-CoV-2 vaccines in development. Nature 2020; 586(7830): 516-27.
[] [PMID: 32967006]

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Article Details

Year: 2021
Published on: 01 April, 2021
Page: [309 - 315]
Pages: 7
DOI: 10.2174/1574887116666210401124945
Price: $65

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