Infection, Infectious Agents and Vascular Disease

Author(s): Nicola Ielapi, Francesco Caprino, Biagio Malizia, Antonio Sisinni, Lwanga Ssempijja, Michele Andreucci, Noemi Licastro, Raffaele Serra*

Journal Name: Reviews on Recent Clinical Trials

Volume 16 , Issue 3 , 2021

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Graphical Abstract:


Background: Infectious agents may be involved in the pathogenesis of vascular disease and related complications. The aim of this review is to analyze the most relevant information on the common infections related to vascular disease, discussing the main pathophysiological mechanisms.

Methods: In the current review, the most important evidence on the issue of infections and vascular disease is searched on Medline, Scopus, and ScienceDirect database.

Results: Among infectious agents, herpesviruses, parvovirus B19, hepatitis viruses, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, treponema pallidum, mycobacterium tuberculosis, pseudomonas aeruginosa, staphylococcus aureus, and candida albicans seem to particularly related to vascular disease.

Conclusion: Infectious agents may affect vessel’s homeostasis and functionality, both on the arterial and venous side, by means of several pathophysiological mechanisms such as dysregulation in vasomotor function, thromboembolic complications, initiation and progression of atherosclerosis, alteration of perivascular adipose tissue, recruiting inflammatory cells and molecules.

Keywords: Infection, vascular disease, infectious agents, artery, vein, inflammation.

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Article Details

Year: 2021
Published on: 25 March, 2021
Page: [262 - 271]
Pages: 10
DOI: 10.2174/1574887116666210325124045
Price: $65

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PDF: 134