The fusion of secretory vesicles with the plasma membrane depends on the assembly of
v-SNAREs (VAMP2/synaptobrevin2) and t-SNAREs (SNAP25/syntaxin1) into the SNARE complex.
Vesicles go through several upstream steps, referred to as docking and priming, to gain fusion
competence. The vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca2+ sensor for fusion
in several central nervous system neurons and neuroendocrine cells and part of the docking complex
for secretory granules. Syt-1 binds to the acceptor complex such as synaxin1, SNAP-25 on the
plasma membrane to facilitate secretory vesicle docking, and upon Ca2+-influx, it promotes vesicle
fusion. This review assesses the role of the Syt-1 protein involved in the secretory vesicle docking,
priming, and fusion.