Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion

Author(s): Najeeb Ullah*, Ezzouhra El Maaiden, Md. Sahab Uddin*, Ghulam Md. Ashraf

Journal Name: Current Protein & Peptide Science

Volume 22 , Issue 6 , 2021


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Abstract:

The fusion of secretory vesicles with the plasma membrane depends on the assembly of v-SNAREs (VAMP2/synaptobrevin2) and t-SNAREs (SNAP25/syntaxin1) into the SNARE complex. Vesicles go through several upstream steps, referred to as docking and priming, to gain fusion competence. The vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca2+ sensor for fusion in several central nervous system neurons and neuroendocrine cells and part of the docking complex for secretory granules. Syt-1 binds to the acceptor complex such as synaxin1, SNAP-25 on the plasma membrane to facilitate secretory vesicle docking, and upon Ca2+-influx, it promotes vesicle fusion. This review assesses the role of the Syt-1 protein involved in the secretory vesicle docking, priming, and fusion.

Keywords: Synaptotagmin-1, vesicle docking, priming, fusion, exocytosis, secretory vesicles.

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Article Details

VOLUME: 22
ISSUE: 6
Year: 2021
Published on: 25 March, 2021
Page: [470 - 478]
Pages: 9
DOI: 10.2174/1389203722666210325110231
Price: $65

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