DILI Cases in Registries and Databases: An Analysis of Quality

Author(s): Rolf Teschke*, Gaby Danan

Journal Name: The International Journal of Gastroenterology and Hepatology Diseases

Volume 1 , Issue 1 , 2022


Article ID: e010621192456
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Abstract:

Data quality of idiosyncratic drug-induced liver injury (iDILI) cases is insufficient in the US LiverTox database due to the lack of a robust causality assessment method such as the Roussel Uclaf Causality Assessment Method (RUCAM), not allowing for appropriate use of included cases by physicians. Despite some shortcomings, case quality is much better in national DILI registries using the prospective RUCAM, with a few exemptions.

Keywords: CAMs, causality assessment methods, DILI, drug-induced liver injury, HILI, herb induced liver injury, Roussel Uclaf Causality Assessment Method, RUCAM, DILI registries, LiverTox.

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2022
Article ID: e010621192456
Pages: 4
DOI: 10.2174/2666290601666210325091553

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