Hypertension is a common chronic disease that particularly affects the elderly and can trigger several
cardiovascular conditions. Although the treatment of hypertension has evolved in recent decades, many hypertensive
patients still do not have properly controlled blood pressure. Accumulating evidence supports the hypothesis
that DNA methylation plays an important role in regulating gene expression, altering the phenotype
and function of the cardiovascular system. The present review highlights recent advances in research on DNA
methylation in the development of hypertension. Several preclinical and clinical evidence show that methylation
of different targets appears to be involved in hypertension. Studies of the involvement of DNA methylation
have greatly improved our understanding of hypertension, but its use as a valid therapeutic target is still unknown.
Further studies could help to bring to light the truth about gene therapy in hypertension.
Keywords: Blood pressure, cardiovascular disease, chronic disease, drug discovery, epigenomic, gene, phenotype.
Rights & PermissionsPrintExport