Tumor-Associated Macrophages as Potential Targets for Anti-Cancer Activity of Marine Invertebrate-Derived Compounds

Author(s): Lyudmila S. Dolmatova*, Igor Y. Dolmatov

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 28 , 2021


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Abstract:

Tumor-associated macrophages (TAMs) are M2 phenotype dominant and promote tumor growth and metastasis. The new cancer treatment strategy includes TAM targeting and is aimed primarily at reprogramming TAMs toward the M1 phenotype or reducing the number and activity of M2 macrophages. Several marine invertebrate-derived drugs, combining efficacy and a low level of side effects, were approved for use in the cancer therapy. The mechanisms of action of some of them include TAM targeting. The review includes data showing immunomodulatory properties of these already approved anticancer drugs and drug candidates in clinical development which additionally incorporate data from screening studies of new substances from marine invertebrates. Based on screening data, the most promising marine compounds for cancer immunotherapy are supposed.

Keywords: Marine invertebrate-derived compounds, tumor-associated macrophages, macrophage reprogramming, cytokines, NO, anticancer drugs, cancer immunotherapy.

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Article Details

VOLUME: 27
ISSUE: 28
Year: 2021
Published on: 19 March, 2021
Page: [3139 - 3160]
Pages: 22
DOI: 10.2174/1381612827666210319125652
Price: $65

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