ACE2 as a Key Target for Treatment of COVID-19 Related Cardiovascular Diseases: Current Progress and Prospect

Author(s): Shuainan Li, Wenya Ma, Fan Yang, Yan Xu, Binbin Xu, Benzhi Cai*

Journal Name: Current Drug Targets

Volume 22 , Issue 16 , 2021

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Graphical Abstract:


ACE2 has long been known as an injury protective protein, which can protect against a variety of organ damage such as the heart, liver, kidney, and lung. Especially in cardiovascular diseases, as a negative regulator of RAAS, ACE2 is an extremely important protective factor that mainly plays a role by converting Ang II to Ang-(1-7). Nevertheless, with the recent outbreak of COVID-19, it is exposed that another identity of ACE2 is the entry receptor for SARS-CoV-2, which previously serves as the entry receptor for SARS. With the in-depth clinical research, it is found that the severity and susceptibility of COVID-19 are related to cardiovascular diseases, and SARS-CoV-2 binding to ACE2 receptor is also potentially associated with heart injury symptoms. Therefore, in this article, we mainly summarize the relationship between ACE2, COVID-19, and cardiovascular diseases/heart injury.

Keywords: COVID-19, cardiovascular diseases, heart injury, SARS-CoV-2, ACE2, RAAS.

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Article Details

Year: 2021
Published on: 19 March, 2021
Page: [1832 - 1843]
Pages: 12
DOI: 10.2174/1389450122666210319110320
Price: $65

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