ACE2 has long been known as an injury protective protein, which can protect against a
variety of organ damage such as the heart, liver, kidney, and lung. Especially in cardiovascular diseases,
as a negative regulator of RAAS, ACE2 is an extremely important protective factor that
mainly plays a role by converting Ang II to Ang-(1-7). Nevertheless, with the recent outbreak of
COVID-19, it is exposed that another identity of ACE2 is the entry receptor for SARS-CoV-2,
which previously serves as the entry receptor for SARS. With the in-depth clinical research, it is
found that the severity and susceptibility of COVID-19 are related to cardiovascular diseases, and
SARS-CoV-2 binding to ACE2 receptor is also potentially associated with heart injury symptoms.
Therefore, in this article, we mainly summarize the relationship between ACE2, COVID-19, and
cardiovascular diseases/heart injury.