Potential Therapeutic Relevance of CRISPR/Cas9 Guided Epigenetic Regulations for Neuropsychiatric Disorders

Author(s): Desh D. Singh*, Ravi Verma, Piyush Parimoo, Ashish Sahu, Vikram Kumar, Era Upadhyay, Dharmendra K. Yadav

Journal Name: Current Topics in Medicinal Chemistry

Volume 21 , Issue 10 , 2021

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Graphical Abstract:


Brain function activity is regulated by several mechanisms of genetic and epigenetic factors such as histone modelling, DNA methylation, and non-coding RNA. Alterations in these regulatory mechanisms affect the normal development of neurons that causes Neuropsychiatric Disorders (ND). However, it is required to analyse the functional significance of neuropsychiatric disorders associated with a molecular mechanism to bring about therapeutic advances in early diagnosis and treatment of the patients. The CRISPR/Cas 9 (Clustered Regularly Interspaced Short Palindromic Repeats) genome editing tools have revolutionized multiple genome and epigenome manipulation targets the same time. This review discussed the possibilities of using CRISPR/Cas 9 tools during molecular mechanism in the ND as a therapeutic approach to overcome ND that is caused due to genetic and epigenetic abnormalities.

Keywords: Neuropsychiatric Disorders, Epigenetic regulations, Transcription factor, CRISPR/Cas9, Gene editing, Neuronal development, Therapeutic applications.

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Article Details

Year: 2021
Published on: 17 March, 2021
Page: [878 - 894]
Pages: 17
DOI: 10.2174/1568026621666210317154502
Price: $65

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