Brain function activity is regulated by several mechanisms of genetic and epigenetic factors
such as histone modelling, DNA methylation, and non-coding RNA. Alterations in these regulatory
mechanisms affect the normal development of neurons that causes Neuropsychiatric Disorders
(ND). However, it is required to analyse the functional significance of neuropsychiatric disorders
associated with a molecular mechanism to bring about therapeutic advances in early diagnosis
and treatment of the patients. The CRISPR/Cas 9 (Clustered Regularly Interspaced Short Palindromic
Repeats) genome editing tools have revolutionized multiple genome and epigenome manipulation
targets the same time. This review discussed the possibilities of using CRISPR/Cas 9 tools
during molecular mechanism in the ND as a therapeutic approach to overcome ND that is caused
due to genetic and epigenetic abnormalities.
Keywords: Neuropsychiatric Disorders, Epigenetic regulations, Transcription factor, CRISPR/Cas9, Gene editing, Neuronal
development, Therapeutic applications.
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