Fontan Circulation Might be Associated with Peripartum Cardiomyopathy: A Review of Mechanistic and Clinical Aspects

(E-pub Ahead of Print)

Author(s): Kenan Yalta, Ertan Yetkin*, Gokay Taylan

Journal Name: Current Cardiology Reviews

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Fontan operation has been defined as a palliative surgery connecting systemic venous return and pulmonary circulation in patients with certain forms of complex congenital heart disease (CHD). Fortunately, it has improved overall survival and chance of successful pregnancies among these patients. However, Fontan circulation (FC), as a potential trade-off, might be associated with specific late or post-gestational complications, including peripartum cardiomyopathy (PPCM) largely through its adverse effects on the placenta and inflammation-oxidation stress. Importantly, diagnosis of superimposed PPCM in women with FC might be a diagnostic challenge, requiring a high index of suspicion. Accordingly, the present paper aims to highlight the potential association of FC with PPCM evolution largely based on certain mechanistic and clinical perspectives.

Keywords: Fontan operation, fontan circulation, peripartum cardiomyopathy, potential mechanisms.

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Article Details

Published on: 16 March, 2021
(E-pub Ahead of Print)
DOI: 10.2174/1573403X17666210316121842
Price: $95

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