Background and Objective: We aimed to examine the differences in life-space mobility
and quality of life (QoL) of patients with cardiovascular disease (CVD) between the pre- and postnationwide
state of emergency initiated by the Coronavirus disease 2019 (COVID-19) pandemic in
Japan and to show the factors associated with the decrease in life-space mobility and QoL in these
Methods: We undertook a longitudinal study of 20 out of 51 consecutive CVD patients with coronary
artery disease (CAD) who met the study criteria. We used the Life-Space Assessment (LSA)
tool to evaluate Life-space mobility and assessed QoL with the five-level EuroQoL five-dimensional
questionnaire (EQ-5D-5L) in Japanese.
Results: The LSA scores and EQ-5D-5L QoL score decreased significantly from the pre- to postnationwide
state of emergency in Japan (p < 0.01). ΔLSA was significantly positively associated
with body mass index and significantly negatively associated with knee extensor muscle strength
and pre-LSA score (p < 0.05). There were no significant relationships between ΔLSA and ΔEQ-
5D-5L QoL scores and between ΔEQ-5D-5L QoL scores and patient characteristics.
Conclusion: The policies promoted to address the state of emergency in Japan might affect life-space
mobility and QoL of CAD patients. Moreover, CAD patients in Japan who were not obese
and maintained their physical function and activity tended to refrain from activity during the period
between the pre- and post-nationwide state of emergency. Clarification of the effects of the
COVID-19 pandemic on the relationship between living space motility and QoL in CAD patients
will require further study.