Background: As one of the effective pharmacological constituents of Ginseng Radix et
Rhizoma, ginsenoside Rh2 (Rh2) exerts a remarkable anticancer effect on various cancer cell lines
in vitro and strongly inhibits tumor growth in vivo without severe toxicity.
Objective: This article reviewed existing evidence supporting the anticancer effects of Rh2 to classify
and conclude previous and current knowledge on the mechanisms and therapeutic effects of
Rh2, as well as to promote the clinical application of this natural product.
Conclusion: This article reviewed the anticancer efficacies and mechanisms of Rh2, including the
induction of cell cycle arrest and programmed cell death, repression of metastasis, alleviation of
drug resistance, and regulation of the immune system. Finally, this paper discussed the research
and application prospects of Rh2.