Anticancer Effects of Ginsenoside Rh2: A Systematic Review

(E-pub Ahead of Print)

Author(s): Xin-Ling He, Xiao-Huang Xu, Jia-Jie Shi, Mingqing Huang, Yitao Wang, Xiuping Chen, Jin-Jian Lu*

Journal Name: Current Molecular Pharmacology


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Abstract:

Background: As one of the effective pharmacological constituents of Ginseng Radix et Rhizoma, ginsenoside Rh2 (Rh2) exerts a remarkable anticancer effect on various cancer cell lines in vitro and strongly inhibits tumor growth in vivo without severe toxicity.

Objective: This article reviewed existing evidence supporting the anticancer effects of Rh2 to classify and conclude previous and current knowledge on the mechanisms and therapeutic effects of Rh2, as well as to promote the clinical application of this natural product.

Conclusion: This article reviewed the anticancer efficacies and mechanisms of Rh2, including the induction of cell cycle arrest and programmed cell death, repression of metastasis, alleviation of drug resistance, and regulation of the immune system. Finally, this paper discussed the research and application prospects of Rh2.

Keywords: Ginseng, ginsenoside Rh2, cancer, cytotoxicity, mechanism, natural compound.

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Article Details

Published on: 08 March, 2021
(E-pub Ahead of Print)
DOI: 10.2174/1874467214666210309115105
Price: $95

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