The present paper elucidates the conceivable application of two key molecules in
SARS-CoV-2 detection of suspected infected persons. These molecules were selected on the basis
of the strong interaction between ACE-2 and S protein that allows virus attachment to its host
cells; on the other hand, specific immunocompetant effectors are generated by the human immune
system during the infection. Several testing procedures are already being used to diagnose SARSCoV-
2 infection, particularly the RT-PCR technique. ELISA and LFIA are possible assays for the
employment of shACE-2/ hAc-anti-S (the molecules of interest) as the main agents of the test that
confer dual principal functions (capture and detection). The future diagnostic kits involving
shACE-2 and hAc-anti-S will possibly be highly sensitive with rapid detection in addition to their
advantage of relatively easy conception. They could be largely considered as technically advanced
kits in regards to the current SARS-CoV-2 diagnostic immunoassays.
Keywords: ACE-2, human antibody, SARS-CoV-2, ELISA, LFIA, diagnosis.
Rights & PermissionsPrintExport