New Perspectives for SARS-CoV-2 Rapid Detection

Title:New Perspectives for SARS-CoV-2 Rapid Detection

Volume: 2 Issue: 12

Author(s): Latifa Khattabi*, Mustapha Mounir Bouhenna and Feriel Sellam

Affiliation:

• National Center of Biotechnology Research Constantine, Ali Mendjli Nouvelle Ville UV 03 BP E73 Constantine ,Algeria

Keywords: ACE-2, human antibody, SARS-CoV-2, ELISA, LFIA, diagnosis.

Abstract: The present paper elucidates the conceivable application of two key molecules in SARS-CoV-2 detection of suspected infected persons. These molecules were selected on the basis of the strong interaction between ACE-2 and S protein that allows virus attachment to its host cells; on the other hand, specific immunocompetant effectors are generated by the human immune system during the infection. Several testing procedures are already being used to diagnose SARSCoV- 2 infection, particularly the RT-PCR technique. ELISA and LFIA are possible assays for the employment of shACE-2/ hAc-anti-S (the molecules of interest) as the main agents of the test that confer dual principal functions (capture and detection). The future diagnostic kits involving shACE-2 and hAc-anti-S will possibly be highly sensitive with rapid detection in addition to their advantage of relatively easy conception. They could be largely considered as technically advanced kits in regards to the current SARS-CoV-2 diagnostic immunoassays.

Cite this article as:

Khattabi Latifa *, Bouhenna Mounir Mustapha and Sellam Feriel , New Perspectives for SARS-CoV-2 Rapid Detection, Coronaviruses 2021; 2 (12) : e080921192113 . https://dx.doi.org/10.2174/2666796702666210308114737