Antifibrotic agents are known to treat idiopathic pulmonary fibrosis. The two antifibrotic
agents approved and in usage are Pirfenidone and Nintedanib granted by the USFDA in 2014.
They are both known to decrease inflammation in the lungs. The fact that COVID-19 has shown to
cause inflammation and fibrosis in the lungs frames the theory of their usage in the treatment of the
disease by reducing lung scaring and allowing faster discharge of patients with post-COVID complications.
The need for them to change their status from orphans to blockbusters has not happened
yet due to fewer data and less research available on them as well as various other economic and patient-
related factors. Since COVID-19 is widespread and causes many complications of the lungs
that are similar to what these two drugs treat. We believe that the status of these drugs could be
changed due to an increase in demand for them.
Keywords: Antifibrotic, COVID-19, Pirfenidone, Nintedanib, Orphan drugs, SARS-CoV-2.
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