Coronavirus disease 2019 (SARS-CoV-2) (COVID-19) has recently raised worldwide public health
concerns. The available data on COVID-19 in patients with diabetes is limited but generally indicate that there
is an increased risk of developing COVID-19 infection in diabetic patients, which ultimately impacts the overall
patient’s survival. Various aspects might be involved; however, the exact mechanisms and interrelationships
between diabetes and the novel COVID-19 have not yet been fully elucidated. This review summarizes the possible
mechanisms by which present diabetes predispose individuals to COVID-19 infection, modulates the hostviral
interactions and increases the risk of mortality. We hope this review can provide beneficial information for
further studies and contribute to improved disease management of diabetic patients with COVID-19.
Keywords: Diabetes, COVID-19, mechanism, risk factor, prognosis, review, SARS-CoV-2.
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