Background: This study aims to investigate the relation between Survivin gene polymorphisms
and the risk of Hepatocellular carcinoma (HCC) resulting from hepatitis C infection among
the Egyptian population.
Methods: This prospective study was conducted on 164 patients, 57 patients were diagnosed with
hepatitis C, where 57 were diagnosed with HCC in addition to 50 healthy volunteers as controls.
Genotyping for Survivin rs1042489 and rs8073069 single nucleotide polymorphisms was carried
out by the allelic discrimination Real-Time Polymerase Chain Reaction Single Nucleotide Polymorphisms
Results: The results of Survivin rs1042489 polymorphism revealed that the TC and CC genotypes
were significantly different between hepatocellular carcinoma patients (OR=15.5, 95%CI:
3.299-72.825,P<0.001), and controls (OR=44, 95%CI: 8.025-241.254, P<0.001). Furthermore, CC
genotype was significantly different between cirrhotic and hepatocellular carcinoma patients
(OR=19.2, 95%CI: 3.097-119.049, P=0.002). Moreover, the TC genotype shows a significant difference
between controls and cirrhotic patients (OR=5.5, 95%CI: 2.111-14.328, P<0.001). However,
when comparing TT genotypes, CC+TC genotypes results showed a significant association with
increasing the risk of cirrhosis and hepatocellular carcinoma (OR=4.812, 95%CI: 1.893-12.233,
P=0.001), (OR=21.607, 95%CI: 4.738-98.532, P<0.01), respectively. On the other hand, there was
no significant difference among all studied groups for all genotypes regarding Survivin rs8073069.
Also, the CC+GC genotype showed no significant association with increased risk of hepatocellular
carcinoma (P=0.999) compared with the GG genotypes.
Conclusion: The study indicates that functional Survivin rs1042489 polymorphism may contribute
to the risk of hepatocellular carcinoma while Survivin rs8073069 polymorphism has no significant
association with increased risk of hepatocellular carcinoma among the studied groups.