Inflammasome research has primarily focused on neurological tissue, particularly
on damaged tissue. Most current neurological literature involves in vivo and in vitro
studies utilizing astroglia, as astroglia express the cytoskeletal glial fibrillary acidic protein
(GFAP), which is used as a hallmark of neuropathological disorders. Research
suggests that astrocytes respond to all forms of neurological damage or disease through
reactive astrogliosis. Additionally, there is a consensus among scientists that inflammasomes
play an important role in neuroinflammation. This review focuses on the latest developments
in inflammasome biology, describing the current understanding of how inflammasomes
can be triggered in the brain and summarizing the literature on the relevance
of inflammasome NLR in prevalent neurological diseases.
Keywords: Astrocytes, inflammasome, neurological diseases, inflammation, signaling, NOD-like receptors.
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