Engineered Polymer Nanoplatforms for Targeted Tumor Cells and Controlled Release Cargos to Enhance Cancer Treatment

Author(s): Zhenjie Wang, Longguang Tang, Qingchun Mu, Siyao Che*, Yongbing Sun*, Lei Bai, Yan Luo, Yeguo Yang, Meng Yu, Zhiqiang Yu*

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 31 , 2021


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Abstract:

Cancer is composed of a series of uncontrollable cells, which finally form tumors to negatively impact the functions of the body and induce other serious diseases, even leading to death. During the last decades, scientists have devoted great efforts to study cancer; however, there are no effective diagnoses and treatments. Nanomaterials have attracted great attention in the biomedical field in recent years, which are widely used as optical imaging probes and delivery systems for cancer therapy. Among the numerous nanomaterials, polymeric nanoparticles occupy a prominent position because of their tunable micro-size, multifunctional surface, prominent biocompatibility and high drug-carrying capacity. These significant advantages of polymeric nanomaterials have significance over the traditional nanomaterials and have become a potential therapy for cancer. In this review, we focus on the applications of polymeric nanoparticles in cancer theranostics, especially as the drug delivery systems for cancer treatment. This review provides an overview on the advancement of synthesis, application of polymeric nanoparticles- based drug delivery systems and highlights the evaluation for cancer therapy.

Keywords: Polymeric nanoparticles, targeted delivery, controlled release, tumor, cancer treatment, malignancy.

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Article Details

VOLUME: 28
ISSUE: 31
Year: 2021
Published on: 26 February, 2021
Page: [6395 - 6410]
Pages: 16
DOI: 10.2174/0929867328666210226143148
Price: $65

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