Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a global
pandemic due to its high transmissibility and pathogenicity. It is a beta clade zoonotic coronavirus
like severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory
syndrome coronavirus (MERS-CoV). Though no effective medication has been developed
against the deadly COVID-19 disease, henceforth old antimicrobial drugs have been repurposed to
treat the COVID-19 patients. In this report, a brief account of the used medication and the potential
mechanism of antimicrobial drugs against SARS-CoV-2 has been provided. Based on the earlier incidences,
the antimicrobials are expected to lose the battle against SARS-CoV-2. The vast lacuna
in the research and development of vaccines has led to overuse of the already formulated antimicrobial
drugs, which in turn has led to a distressing problem called “Antimicrobial resistance (AMR)”.
A complete assay of AMR has been given including its cause, mechanism, spread, and consequences.
The other two interlinked problems, namely environmental deterioration and secondary infections,
are elaborated. Moreover, to combat the AMR problem, the way forward has been discussed