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Current Women`s Health Reviews

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ISSN (Print): 1573-4048
ISSN (Online): 1875-6581

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Review Article

Fresh or Frozen Embryo Selection in Embryo Transfer: Live Birth Rates and Obstetric and Fetal/Neonatal Results

Author(s): Nurcan Kirca and Meryem Öngen*

Volume 18, Issue 1, 2022

Published on: 23 February, 2021

Article ID: e221121191752 Pages: 10

DOI: 10.2174/1573404817666210223163145

Price: $65

Abstract

Assisted reproductive techniques used in the treatment of infertility have been promising methods for infertile individuals. Embryo selection and embryo transfer are an important part of assisting reproductive techniques. The selection of the embryo to be transferred is important for implantation and clinical pregnancy success. In addition, whether to use a fresh embryo or frozen embryo for embryo transfer is a controversial issue. While the fresh embryo transfer technique is widely used, the frozen embryo transfer technique has become widespread. The main factor in choosing the method of freezing the embryos is to avoid the negative effects of controlled ovarian hyperstimulation on endometrial receptivity. Therefore, it is thought that the use of frozen embryos can improve pregnancy outcomes and reduce the risk of developing obstetric and perinatal problems. However, there are problems in the embryo freezing technique, such as the risk of developing degeneration in the embryo during the freezing or thawing process and postponing the transfer. In addition, adverse conditions have been reported, such as an increased risk of developing hypertensive disorders in the mother and macrosomia in the baby.

Keywords: Embryo transfer, fetal, fresh embryo, frozen embryo, neonatal, pregnancy

Graphical Abstract

[1]
Direkvand-Moghadam A, Delpisheh A, Khosravi A. Epidemiology of female infertility; a review of literature. Biosci Biotechnol Res Asia 2013; 10(2): 559-67.
[http://dx.doi.org/10.13005/bbra/1165]
[2]
Wong KM, Mastenbroek S, Repping S. Cryopreservation of human embryos and its contribution to in vitro fertilization success rates. Fertil Steril 2014; 102(1): 19-26.
[http://dx.doi.org/10.1016/j.fertnstert.2014.05.027] [PMID: 24890275]
[3]
Roque M, Valle M, Kostolias A, Sampaio M, Geber S. Freeze-all cycle in reproductive medicine: current perspectives. JBRA Assist Reprod 2017; 21(1): 49-53.
[http://dx.doi.org/10.5935/1518-0557.20170012] [PMID: 28333033]
[4]
Cseh S, Corselli J, Nehlsen-Cannarella SL, Bailey LL, Szalay AA. The effect of quick-freezing in ethylene glycol on morphological survival and in vitro development of mouse embryos frozen at different preimplantation stages. Theriogenology 1997; 48(1): 43-50.
[http://dx.doi.org/10.1016/S0093-691X(97)00190-8] [PMID: 16728106]
[5]
Cryopreservation of gametes and embryos. In vitro Fertilziation. 3rd ed. Cambridge University Press 2011; pp. 191-215.
[6]
Stachecki JJ, Cohen J. An overview of oocyte cryopreservation. Reprod Biomed Online 2004; 9(2): 152-63.
[http://dx.doi.org/10.1016/S1472-6483(10)62124-4] [PMID: 15333244]
[7]
Zeilmaker GH, Alberda AT, van Gent I, Rijkmans CM, Drogendijk AC. Two pregnancies following transfer of intact frozen-thawed embryos. Fertil Steril 1984; 42(2): 293-6.
[http://dx.doi.org/10.1016/S0015-0282(16)48029-5] [PMID: 6745463]
[8]
Pereira M, Samorinha C, Alves E, Machado H, Amorim M, Silva S. Patients’ views on the embryo storage time limits. Reprod Biomed Online 2015; 31(2): 232-8.
[http://dx.doi.org/10.1016/j.rbmo.2015.04.015] [PMID: 26096027]
[9]
Presidency of the Republic of Turkey, Regulatory Information System Regulation on assistant reproductive treatment applications and assistant reproductive treatment centers, 2014: Official Gazette no 29135 Available from: https://www.mevzuat.gov.tr/mevzuat?MevzuatNo=20085&MevzuatTur= 7&MevzuatTertip=5
[10]
Healy MW, Patounakis G, Connell MT, Devine K, DeCherney AH, Levy MJ. Does a frozen embryo transfer ameliorate the effect of elevated progesterone seen in fresh transfer cycles? Fertil Steril 2016; 105(1): 93-9.
[http://dx.doi.org/10.1016/j.fertnstert.2015.09.015]
[11]
Cobo A, Garrido N, Crespo J, José R, Pellicer A. Accumulation of oocytes: a new strategy for managing low-responder patients. Reprod Biomed Online 2012; 24(4): 424-32.
[http://dx.doi.org/10.1016/j.rbmo.2011.12.012] [PMID: 22386762]
[12]
Davenport MJ, Vollenhoven B, Talmor AJ. Gonadotropin-releasing hormone-agonist triggering and a freeze-all approach: The final step in eliminating ovarian hyperstimulation syndrome? Obstet Gynecol Surv 2017; 72(5): 296-308.
[http://dx.doi.org/10.1097/OGX.0000000000000432] [PMID: 28558117]
[13]
Hammarberg K, Kirkman M, Stern C, et al. Cryopreservation of reproductive material before cancer treatment: a qualitative study of health care professionals’ views about ways to enhance clinical care. BMC Health Serv Res 2017; 17(1): 343.
[http://dx.doi.org/10.1186/s12913-017-2292-2] [PMID: 28490359]
[14]
Zhao J, Xu B, Zhang Q, Li YP. Which one has a better obstetric and perinatal outcome in singleton pregnancy, IVF/ICSI or FET?: a systematic review and meta-analysis. Reprod Biol Endocrinol 2016; 14(1): 51.
[http://dx.doi.org/10.1186/s12958-016-0188-3] [PMID: 27577996]
[15]
Maheshwari A, Pandey S, Amalraj Raja E, Shetty A, Hamilton M, Bhattacharya S. Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer? Hum Reprod Update 2018; 24(1): 35-58.
[http://dx.doi.org/10.1093/humupd/dmx031] [PMID: 29155965]
[16]
Vernon M, Stern JE, Ball GD, Wininger D, Mayer J, Racowsky C. Utility of the national embryo morphology data collection by the Society for Assisted Reproductive Technologies (SART): correlation between day-3 morphology grade and live-birth outcome. Fertil Steril 2011; 95(8): 2761-3.
[http://dx.doi.org/10.1016/j.fertnstert.2011.02.008] [PMID: 21406305]
[17]
Mirkin S, Nikas G, Hsiu JG, Díaz J, Oehninger S. Gene expression profiles and structural/functional features of the peri-implantation endometrium in natural and gonadotropin-stimulated cycles. J Clin Endocrinol Metab 2004; 89(11): 5742-52.
[http://dx.doi.org/10.1210/jc.2004-0605] [PMID: 15531538]
[18]
Rienzi L, Gracia C, Maggiulli R, et al. Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance. Hum Reprod Update 2017; 23(2): 139-55.
[PMID: 27827818]
[19]
Gomaa H, Baydoun R, Sachak S, Lapana I, Soliman S. Elective single embryo transfer: Is frozen better than fresh? JBRA Assist Reprod 2016; 20(1): 3-7.
[http://dx.doi.org/10.5935/1518-0557.20160002] [PMID: 27203298]
[20]
Stanhiser J, Hayward B, Ansari S, Mahony MC, Fritz MA, Mersereau JE. Fresh transfer compared to primary frozen embryo transfer (FET): retrospective analysis of demographics, cycle characteristics and implantation, pregnancy, and live birth rates. Fertil Steril 2017; 108(3): 330-1.
[http://dx.doi.org/10.1016/j.fertnstert.2017.07.972]
[21]
Xu B, He YQ, Wang Y, et al. Frozen embryo transfer or fresh embryo transfer: Clinical outcomes depend on the number of oocytes retrieved. Eur J Obstet Gynecol Reprod Biol 2017; 215: 50-4.
[http://dx.doi.org/10.1016/j.ejogrb.2017.05.023] [PMID: 28600920]
[22]
Shi Y, Sun Y, Hao C, et al. Transfer of Fresh versus Frozen Embryos in Ovulatory Women. N Engl J Med 2018; 378(2): 126-36.
[http://dx.doi.org/10.1056/NEJMoa1705334] [PMID: 29320646]
[23]
Kalem Z, Namli Kalem M, Ruso H, Bakirarar B, Gurgan T. Fresh versus frozen-thawed blastocyst transfer in high responders. Ginekol Pol 2018; 89(8): 407-13.
[http://dx.doi.org/10.5603/GP.a2018.0070] [PMID: 30215458]
[24]
Zhang W, Xiao X, Zhang J, et al. Clinical outcomes of frozen embryo versus fresh embryo transfer following in vitro fertilization: a meta-analysis of randomized controlled trials. Arch Gynecol Obstet 2018; 298(2): 259-72.
[http://dx.doi.org/10.1007/s00404-018-4786-5] [PMID: 29881888]
[25]
Biliangady R, Pandit R, Tudu NK, et al. Is it time to move toward freeze-all strategy? - A retrospective study comparing live birth rates between fresh and first frozen blastocyst transfer. J Hum Reprod Sci 2019; 12(4): 321-6.
[http://dx.doi.org/10.4103/jhrs.JHRS_146_18] [PMID: 32038083]
[26]
Wei D, Liu JY, Sun Y, et al. Frozen versus fresh single blastocyst transfer in ovulatory women: A multicentre, randomised controlled trial. Lancet 2019; 393(10178): 1310-8.
[http://dx.doi.org/10.1016/S0140-6736(18)32843-5] [PMID: 30827784]
[27]
Wu J, Yang X, Huang J, Kuang Y, Wang Y. Fertility and neonatal outcomes of freeze-all vs. fresh embryo transfer in women with advanced endometriosis. Front Endocrinol (Lausanne) 2019; 10: 770.
[http://dx.doi.org/10.3389/fendo.2019.00770] [PMID: 31787933]
[28]
Sik A, Oral S, Aba YA, Ozolcay O, Koc M, Sismanoglu A. Pregnancy results after fresh embryo transfer and selective frozen-thawed embryo transfer: Single-center experience. J Gynecol Obstet Hum Reprod 2020; 49(4): 101707.
[http://dx.doi.org/10.1016/j.jogoh.2020.101707] [PMID: 32018049]
[29]
Haas J, Meriano J, Laskin C, et al. Clinical pregnancy rate following frozen embryo transfer is higher with blastocysts vitrified on day 5 than on day 6. J Assist Reprod Genet 2016; 33(12): 1553-7.
[http://dx.doi.org/10.1007/s10815-016-0818-x] [PMID: 27714479]
[30]
Barrenetxea G, López de Larruzea A, Ganzabal T, Jiménez R, Carbonero K, Mandiola M. Blastocyst culture after repeated failure of cleavage-stage embryo transfers: a comparison of day 5 and day 6 transfers. Fertil Steril 2005; 83(1): 49-53.
[http://dx.doi.org/10.1016/j.fertnstert.2004.06.049] [PMID: 15652886]
[31]
Shapiro BS, Richter KS, Harris DC, Daneshmand ST. A comparison of day 5 and day 6 blastocyst transfers. Fertil Steril 2001; 75(6): 1126-30.
[http://dx.doi.org/10.1016/S0015-0282(01)01771-X] [PMID: 11384637]
[32]
Kovacic B, Vlaisavljević V, Reljic M, Gavrić Lovrec V. Clinical outcome of day 2 versus day 5 transfer in cycles with one or two developed embryos. Fertil Steril 2002; 77(3): 529-36.
[http://dx.doi.org/10.1016/S0015-0282(01)03212-5] [PMID: 11872208]
[33]
Huisman GJ, Fauser BC, Eijkemans MJ, Pieters MH. Implantation rates after in vitro fertilization and transfer of a maximum of two embryos that have undergone three to five days of culture. Fertil Steril 2000; 73(1): 117-22.
[http://dx.doi.org/10.1016/S0015-0282(99)00458-6] [PMID: 10632424]
[34]
Imudia AN, Awonuga AO, Kaimal AJ, Wright DL, Styer AK, Toth TL. Elective cryopreservation of all embryos with subsequent cryothaw embryo transfer in patients at risk for ovarian hyperstimulation syndrome reduces the risk of adverse obstetric outcomes: a preliminary study. Fertil Steril 2013; 99(1): 168-73.
[http://dx.doi.org/10.1016/j.fertnstert.2012.08.060] [PMID: 23025881]
[35]
Maheshwari A, Pandey S, Shetty A, Hamilton M, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril 2012; 98(2): 368-77.e1, 9.
[http://dx.doi.org/10.1016/j.fertnstert.2012.05.019] [PMID: 22698643]
[36]
Kansal Kalra S, Ratcliffe SJ, Milman L, Gracia CR, Coutifaris C, Barnhart KT. Perinatal morbidity after in vitro fertilization is lower with frozen embryo transfer. Fertil Steril 2011; 95(2): 548-53.
[http://dx.doi.org/10.1016/j.fertnstert.2010.05.049] [PMID: 20663500]
[37]
Sha T, Yin X, Cheng W, Massey IY. Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis. Fertil Steril 2018; 109(2): 330-42.
[http://dx.doi.org/10.1016/j.fertnstert.2017.10.019]
[38]
Roque M, Valle M, Sampaio M, Geber S. Obstetric outcomes after fresh versus frozen-thawed embryo transfers: A systematic review and meta-analysis. JBRA Assist Reprod 2018; 22(3): 253-60.
[http://dx.doi.org/10.5935/1518-0557.20180049] [PMID: 29782139]
[39]
Sites CK, Wilson D, Barsky M, et al. Embryo cryopreservation and preeclampsia risk. Fertil Steril 2017; 108(5): 784-90.
[http://dx.doi.org/10.1016/j.fertnstert.2017.08.035] [PMID: 28974308]
[40]
Knöfler M, Haider S, Saleh L, Pollheimer J, Gamage TKJB, James J. Human placenta and trophoblast development: key molecular mechanisms and model systems. Cell Mol Life Sci 2019; 76(18): 3479-96.
[http://dx.doi.org/10.1007/s00018-019-03104-6] [PMID: 31049600]
[41]
Zhang X, Decker A, Platt RW, Kramer MS. How big is too big? The perinatal consequences of fetal macrosomia. Am J Obstet Gynecol 2008; 198(5): 517.e1-6.
[http://dx.doi.org/10.1016/j.ajog.2007.12.005] [PMID: 18455528]
[42]
Schellong K, Schulz S, Harder T, Plagemann A. Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally. PloS One 2012; 7(10): e47776.
[43]
Li Y, Wu J, Yu J, et al. EBM-CONNECT Collaboration. Is fetal macrosomia related to blood pressure among adolescents? A birth cohort study in China. J Hum Hypertens 2013; 27(11): 686-92.
[http://dx.doi.org/10.1038/jhh.2013.31] [PMID: 23595162]
[44]
Chen ZJ, Shi Y, Sun Y, et al. Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome. N Engl J Med 2016; 375(6): 523-33.
[http://dx.doi.org/10.1056/NEJMoa1513873] [PMID: 27509101]
[45]
Litzky JF, Boulet SL, Esfandiari N, et al. Effect of frozen/thawed embryo transfer on birthweight, macrosomia, and low birthweight rates in US singleton infants. Am J Obstet Gynecol 2018; 218(4): 433.e1-433.e10.
[http://dx.doi.org/10.1016/j.ajog.2017.12.223] [PMID: 29291410]
[46]
Zhang J, Du M, Li Z, et al. Fresh versus frozen embryo transfer for full-term singleton birth: a retrospective cohort study. J Ovarian Res 2018; 11(1): 59.
[http://dx.doi.org/10.1186/s13048-018-0432-x] [PMID: 30012201]
[47]
Johnson KM, Hacker MR, Resetkova N, O’Brien B, Modest AM. Risk of ischemic placental disease in fresh and frozen embryo transfer cycles. Fertil Steril 2019; 111(4): 714-21.
[http://dx.doi.org/10.1016/j.fertnstert.2018.11.043] [PMID: 30826115]
[48]
Laval M, Garlantézec R, Guivarc’h-Levêque A. Birthweight difference of singletons conceived through in vitro fertilization with frozen versus fresh embryo transfer: An analysis of 5406 embryo transfers in a retrospective study 2013-2018. J Gynecol Obstet Hum Reprod 2020; 49(1)
[http://dx.doi.org/10.1016/j.jogoh.2019.101644] [PMID: 31593781]
[49]
Sacha CR, Harris AL, James K, et al. Placental pathology in live births conceived with in vitro fertilization after fresh and frozen embryo transfer. Am J Obstet Gynecol 2020; 222(4): 360.e1-360.e16.
[http://dx.doi.org/10.1016/j.ajog.2019.09.047] [PMID: 31589863]

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