Background: The effects of chemotherapeutics agents are considered to influence the
immune system and cells due to their myelosuppressive and immunosuppressive functions. Natural
killer cells are one of the important components of the innate immune system and have a critical
role against tumor cells and infections.
Objective: The study was aimed to demonstrate whether conventional chemotherapies had an effect
on Natural Killer (NK) cell activity.
Methods: Forty-nine adjuvant and 19 first-time metastatic chemotherapy-naïve cancer patients
were recruited into the study. Blood samples at pre-chemotherapy and post-chemotherapy, at 1st
and 4th cycles, were obtained for NK cell activity.
Results: We found no difference between baseline and post-chemotherapy NK cell activity levels.
In addition, we found no difference between pre-chemotherapy and post-chemotherapy NK cell activity
in both adjuvant and metastatic cancer patients separately.
Conclusion: Conventional chemotherapy seems to have no effect on NK cell activity levels in cancer
patients in both metastatic and adjuvant settings.