Aim and Objective: Herein, A series of new imidazo[1,2-a]pyridine-chalcone derivatives
3a-m were designed and synthesized to find a new class of antibacterial agents. These compounds
were prepared by the aldol condensation of 2-phenylimidazo[1,2-a]pyridine-3-carbaldehyde
2a-b with acetophenone derivatives and other aromatic acetyls. High reaction yields were obtained
in a short reaction time, through applying this multi-step pathway.
Materials and Methods: In vitro antibacterial activities of the synthesized imidazo[1,2-a]pyridinechalcones
were measured against S. aureus, B. subtilis and E. coli with MIC values of 32 -128
μg/mL. Finally, essential structural analyses such as CHN and NMR spectroscopies were used to
identify the synthesized chalcones based on imidazo[1,2-a]pyridine derivatives.
Results: The results showed that most of the products presented moderate to good antibacterial activities.
Compounds 3b, 3d, 3g, 3l and 3m revealed obvious potency against S. aureus, B. subtilis
and E. coli with MIC values of 32 μg/mL and 64 μg/mL, which were better when compared with
Conclusion: The synthesized antibacterial compounds were obtained with appealing advantages
such as high purity, simple pathway, good to excellent yields, inexpensive and easy availability of
materials as well as good activities against bacteria. So in this work, a new class of antibacterial
chalcones based on imidazo[1,2-a]pyridine has been reported.