Design and Evaluation of Sustained Release of Ornidazole by Dental Inserts

Author(s): Sunchu Harika*, Y. Shravan Kumar*, Y. Madhusudhan Rao, Pavani Sriram, Uma Shankar

Journal Name: Current Drug Metabolism

Volume 22 , Issue 7 , 2021

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Graphical Abstract:


Aim & Background: Ornidazole is an antimicrobial drug used to treat certain types of vaginal, urinary tract, and interstitial infections. The study aims to formulate and evaluate the dental inserts by using a drug candidate to sustained drug release to improve patient compliance, reduce dosing frequency, reduce the risk of dose dumping, and avoid the first-pass metabolism. They have better therapeutic efficacy and fewer side effects.

Methods: The dental inserts were prepared using various polymers alone and in combination with the different ratios of polymers. The evaluation parameters like thickness, drug content, content uniformity, moisture reuptake, weight variation, swelling studies, and erosion studies of the optimized inserts were studied. The in-vivo studies were conducted to determine the reduction of pocket depth in human volunteers.

Results: The system containing ethylcellulose and hydroxyl methyl propyl cellulose K100M (4:1) formulation F6 was optimized because drug release was sustained up to 120 hrs concerning other formulations. Optimized formulation followed first-order kinetics and Peppas release kinetics via fickian diffusion. There was no swelling, itching, irritation, and no reduction in the pocket depth in in-vivo studies.

Conclusion: The study concluded that dental inserts could extend the release of Ornidazole for many hours and also enhance bioavailability. Furthermore, they also help in avoiding the first-pass effect. In vivo studies’ observations showed no itching, irritation, swelling, and pocket-depth reduction.

Keywords: Intra pocket drug delivery, sustained-release, periodontal disease, pocket depth, enhanced bioavailability, ethylcellulose, anaerobic bacteria, minimum inhibitory concentration.

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Article Details

Year: 2021
Published on: 22 February, 2021
Page: [572 - 580]
Pages: 9
DOI: 10.2174/1389200222666210222152940
Price: $65

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PDF: 142