With the introduction of systems theory to genetics, numerous opportunities for genomic
research have been identified. Consequences of DNA sequence variations are systematically
evaluated using the network- or pathway-based analysis, a technological basis of systems biology
or, more precisely, systems genomics. Despite comprehensive descriptions of advantages offered
by systems genomic approaches, pathway-based analysis is uncommon in cytogenetic (cytogenomic)
studies, i.e. genome analysis at the chromosomal level. Here, we would like to express our
opinion that current cytogenomics benefits from the application of systems biology methodology.
Accordingly, systems cytogenomics appears to be a biomedical area requiring more attention than
it actually receives.