Chemical Constituents and Biological Activities of the Genus Flindersia (Rutaceae)

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Author(s): Lara Pessanha Soares Nascimento*, Michel de Souza Passos, Thalya Soares Ribeiro Nogueira, Mayara Barreto de Souza Arantes, Noemi Oliveira Monteiro, Samyra Imad da Silva Boeno, Antônio Sérgio Nascimento Moreira, Milena Gonçalves Curcino Vieira, Almir Ribeiro de Carvalho Júnior, Raimundo Braz-Filho, Ivo José Curcino Vieira

Journal Name: Mini-Reviews in Organic Chemistry

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The genus Flindersia comprises 17 species distributed in Australia, New Caledonia, New Guinea, and the Maluku Islands. With a variety of classes of secondary metabolites, including terpenes, alkaloids, lignans, flavonoids, coumarins, among other compounds, to date the genus has not been widely studied phytochemically, having more value in the timber industry. However, the objective of this review is to gather the necessary information for future research on this genus, for the inclusion of new chemical constituents and biological activities. Thus, we show that the genus Flindersia has more than 160 isolated or identified compounds. In addition, the alkaloids in this genus confer antimalarial activity.

Keywords: Flindersia, secondary metabolites, biological activities, terpenes, alkaloids, phenolic compounds, antifeedant activity.

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(E-pub Ahead of Print)
DOI: 10.2174/1570193X18666210218213410
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