Hippocampal and Amygdalar Morphological Abnormalities in Alzheimer’s Disease Based on Three Chinese MRI Datasets

Author(s): Yuanyuan Wei, Nianwei Huang, Yong Liu, Xi Zhang*, Silun Wang*, Xiaoying Tang*

Journal Name: Current Alzheimer Research

Volume 17 , Issue 13 , 2020


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Abstract:

Background: Early detection of Alzheimer’s disease (AD) and its early stage, the mild cognitive impairment (MCI), has important scientific, clinical and social significance. Magnetic resonance imaging (MRI) based statistical shape analysis provides an opportunity to detect regional structural abnormalities of brain structures caused by AD and MCI.

Objective: In this work, we aimed to employ a well-established statistical shape analysis pipeline, in the framework of large deformation diffeomorphic metric mapping, to identify and quantify the regional shape abnormalities of the bilateral hippocampus and amygdala at different prodromal stages of AD, using three Chinese MRI datasets collected from different domestic hospitals.

Methods: We analyzed the region-specific shape abnormalities at different stages of the neuropathology of AD by comparing the localized shape characteristics of the bilateral hippocampi and amygdalas between healthy controls and two disease groups (MCI and AD). In addition to group comparison analyses, we also investigated the association between the shape characteristics and the Mini Mental State Examination (MMSE) of each structure of interest in the disease group (MCI and AD combined) as well as the discriminative power of different morphometric biomarkers.

Results: We found the strongest disease pathology (regional atrophy) at the subiculum and CA1 subregions of the hippocampus and the basolateral, basomedial as well as centromedial subregions of the amygdala. Furthermore, the shape characteristics of the hippocampal and amygdalar subregions exhibiting the strongest AD related atrophy were found to have the most significant positive associations with the MMSE. Employing the shape deformation marker of the hippocampus or the amygdala for automated MCI or AD detection yielded a significant accuracy boost over the corresponding volume measurement.

Conclusion: Our results suggested that the amygdalar and hippocampal morphometrics, especially those of shape morphometrics, can be used as auxiliary indicators for monitoring the disease status of an AD patient.

Keywords: Alzheimer's disease, mild cognitive impairment, shape analysis, MMSE, large deformation diffeomorphic metric mapping, multiple datasets.

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Article Details

VOLUME: 17
ISSUE: 13
Year: 2020
Page: [1221 - 1231]
Pages: 11
DOI: 10.2174/1567205018666210218150223
Price: $65

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