Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases

Author(s): Rokeya Akter, Habibur Rahman*, Tapan Behl, Mohammad Arifur Rahman Chowdhury, Mohammad Manirujjaman, Israt Jahan Bulbul, Shimaa E. Elshenaw, Delia Mirela Tit, Simona Bungau

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 20 , Issue 5 , 2021

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Graphical Abstract:


Aging is an important stage of the human life cycle and the primary risk factor for Neurodegenerative Diseases (ND). The aging process contributes to modifications in cells, which may lead to a lack of nutrient signaling, disrupted cellular activity, increased oxidative pressure, cell homeostasis depletion, genomic instability, misfolded protein aggregation, impaired cellular protection, and telomere reduction. The neuropathologies found in Alzheimer's Disease (AD) and Parkinson's Disease (PD) are internally and extrinsically compound environmental stressors which may be partially alleviated by using different phytochemicals. The new therapies for ND are restricted as they are primarily targeted at final disease progression, including behavioral shifts, neurological disorders, proteinopathies and neuronal failure. This review presents the role of phytochemicals-related polyphenolic compounds as an accompanying therapy model to avoid neuropathologies linked to AD, PD and to simultaneously enhance two stochastic stressors, namely inflammation and oxidative stress, promoting their disease pathologies. Therefore, this approach represents a prophylactic way to target risk factors that rely on their action against ND that does not occur through current pharmacological agents over the life of a person.

Keywords: Neurodegeneration, polyphenols, inflammation, reactive oxygen species, AD, PD.

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Article Details

Year: 2021
Published on: 17 February, 2021
Page: [430 - 450]
Pages: 21
DOI: 10.2174/1871527320666210218084444
Price: $65

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