Origins, Structures, and Bioactivities of Secondary Metabolites from Marine- derived Penicillium Fungi

(E-pub Ahead of Print)

Author(s): Xiliang Yang*, Jinping Liu, Jiahui Mei, Rui Jiang, Shizheng Tu, Huafeng Deng, Jing Liu, Sumei Yang, Juan Li*

Journal Name: Mini-Reviews in Medicinal Chemistry

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In recent years, marine-derived Penicillium fungi have received remarkable interest as a valuable source of novel natural products encompassing diverse chemical structures and bioactive properties. Mangroves, sediments, algae, and sponges are the four main sources of marine-derived Penicillium fungi. As of 2014, more than 390 novel natural products have been isolated from the marine-derived Penicillium fungi, mainly including polyketides, alkaloids, terpenoids, and macrolides. Biological investigations have shown that these compounds possess antimicrobial, anti-inflammatory, cytotoxic, and other activities with potential applications in new drug development. To provide an updated catalog of this field, our mini-review summarized the origins, structures, and bioactivities of 188 secondary metabolites from marine-derived Penicillium fungi based on bioactivities classification published from 2015 to 2020.

Keywords: Penicillium, secondary metabolite, marine fungus, antimicrobial, cytotoxicity, enzymatic activity.

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(E-pub Ahead of Print)
DOI: 10.2174/1389557521666210217093517
Price: $95

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