A Review on Rotenoids: Purification, Characterization and its Biological Applications

Author(s): Praveen Kumar P.K*, Priyadharshini A, Sivanandham Muthukumaran

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 21 , Issue 13 , 2021

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Graphical Abstract:


Phytochemicals play a vital role as drugs for the treatment of various autoimmune, viral, and cancerous diseases. Rotenoids, a type of isoflavone compounds present in plants genus Boerhaavia sp., Mirabilis sp. and Abronia sp. which belong to the Nyctaginaceae family, are traditionally used as pesticides and insecticides. Boeravinones are groups of rotenoid compounds widely used as drugs or drug adjuvants for the treatment of various diseases. Extraction of rotenoids in various solvents, purification of rotenoids in various chromatographic technique studies, and the characterization of functional groups of rotenoids in various spectroscopic techniques have been reported. Biological applications of rotenoids such as anti-cancerous, antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities have been discussed. This review summarizes the extraction, isolation, purification, and characterization of rotenoid compounds and their effect on the treatment of cancer, inflammatory, spasmolytic, autoimmune, and microbial diseases.

Keywords: Rotenoid, boeravinone, boerhaavia diffusa linn, mirabilis jalapa, abronia nana.

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Article Details

Year: 2021
Published on: 16 February, 2021
Page: [1734 - 1746]
Pages: 13
DOI: 10.2174/1389557521666210217092634
Price: $65

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