COVID-19 is currently threatening the globe. SARS-CoV-2 is the cause of COVID-19, which spreads via droplets/airborne and direct contact. Health care workers (HCWs) are the frontline workers, which are directly involved in taking care of patients affected by COVID-19. HCWs are at a higher risk of infection during the caring of COVID-19 patients. In this focused review, we have highlighted the higher risk for COVID-19 infection among health care professionals during close contact with patients and their preventive management in COVID-19 pandemic.