The chemistry and pharmacology of the important Vinca alkaloids such as vinblastine
and vincristine used in anticancer therapy are still investigated widely. Several new
derivatives, e.g., vinflunine, vinorelbine, and vindesine, have been synthesized and become
successful medicines in anti-cancer therapy. In 2012, we published a paper that reviewed the
Vinca derivatives. Nevertheless, the interest in the preparation of new modified structures is
not decreasing either in recent years. In this review, the vinblastine-type molecules with several
substituents, e.g., amide, nitrile, hydrazide, substituted side chains, etc. in different positions
of catharanthine and/or vindoline cores are presented. An important part of the review is
the derivatization of the monomer alkaloid vindoline, which possesses no antitumor effect.
Additionally, new hybrid molecules of these alkaloids are also discussed in this mini-review.