Ultrasound-Triggered Immunotherapy for Cancer Treatment: An Update

Author(s): Debasmita Mukhopadhyay, Amal Ahmed, Catherine Sano, Nahid Awad, Nour Al Sawaftah, Ghaleb A. Husseini*

Journal Name: Current Protein & Peptide Science

Volume 22 , Issue 6 , 2021


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Abstract:

Over the past few decades, immunotherapy has emerged as a promising therapeutic approach to treat some types of cancer. Moreover, antibody-based cancer therapies can trigger apoptosis and cell growth inhibition to induce immune cell destruction of target cells through antibody-dependent cellular cytotoxicity (ADCC). Nevertheless, immunotherapeutic efficiency is often restricted due to deficient delivery or low accumulation of therapeutic molecules at the tumor site. The development of pegylated liposomes with monoclonal antibodies conjugated to their surfaces (immunoliposomes) and triggered with ultrasound can effectively improve drug accessibility by enhancing cell membrane permeability and drug release. This review summarizes existing traditional cancer treatments and their limitations, emphasizing the recent advancements in ultrasound-triggered immunotherapy.

Keywords: Ultrasound, immunotherapy, liposome, microbubbles, cancer, cell growth.

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Article Details

VOLUME: 22
ISSUE: 6
Year: 2021
Published on: 12 February, 2021
Page: [493 - 504]
Pages: 12
DOI: 10.2174/1389203722666210212125526
Price: $65

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