Ultrasound-triggered Immunotherapy for Cancer Treatment: An Update

(E-pub Ahead of Print)

Author(s): Debasmita Mukhopadhyay, Amal Ahmed, Catherine Sano, Nahid Awad, Nour AlSawaftah, Ghaleb A Husseini*

Journal Name: Current Protein & Peptide Science


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Abstract:

Over the past few decades, immunotherapy has emerged as a promising therapeutic approach to treat some types of cancer. Moreover, antibody-based cancer therapies can trigger apoptosis and cell growth inhibition to induce immune cell destruction of target cells through antibody-dependent cellular cytotoxicity (ADCC). Nevertheless, immunotherapeutic efficiency is often restricted to either deficient delivery or low accumulation of therapeutic molecules at the tumor site. Therefore, exposing immunoliposomes to ultrasound can effectively improve drug accessibility by enhancing cell membrane permeability and drug release. This review summarizes existing traditional cancer treatments and their limitations, emphasizing the recent advancements in ultrasound-triggered immunotherapy.

Keywords: Ultrasound, immunotherapy, liposome, microbubbles, cancer, cell growth

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Article Details

Published on: 12 February, 2021
(E-pub Ahead of Print)
DOI: 10.2174/1389203722666210212125526
Price: $95

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