An efficient one-pot stereoselective synthesis of 2,6-disubstituted 4-thiocyanatotetrahydropyrans

(E-pub Abstract Ahead of Print)

Author(s): Chithaluri Sudhakar*, Pochamoni Ramudu

Journal Name: Current Organocatalysis


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Abstract:

An efficient stereoselective synthesis of 2,6-disubstituted-4-thiocyanatotetrahydropyrans has been developed through a one pot three-component reaction of aldehydes, trimethyl allylsilane and NH4SCN in the presence of BF3.Et2O at room temperature. The products are formed rapidly (10-30 min) in excellent yields (78-98%).

Keywords: Aldehydes, Allyl trimethylsilane, Lewis acid, Prins cyclization, thiocyanatotetrahydropyran, one-pot reaction

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/2213337208666210212121506
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