Natural products have served as a limitless reservoir of bioactive scaffolds for drug discovery against
several disorders. Furanodiene is a bioactive natural product isolated from several plants of genus Curcuma. Its
therapeutic potential against cancer, inflammation, and angiogenesis has been well-documented. The current
review is an update about the natural sources and anti-cancer action mechanism of furanodiene. Furanodiene
exerts its anti-cancer effects via induction of apoptosis in several cancer types by modulating MAPKs/ERK,
NF-κB, and Akt pathways. Furanodiene has been systematically studied for its anti-cancer potential. However,
pharmacokinetics, pharmacodynamics, pre-clinical and clinical studies still needed to be conducted to completely
validate the potential of furanodiene for the treatment of cancer.
Keywords: Furanodiene, natural compound, terpenoid, sesquiterpene, anti-cancer, antioxidant, Curcuma.
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