Background: Ovarian Cancer (OC) remains the first leading cause of gynecologic malignancy.
The survival rate from Serous Ovarian Cancer (SOC) is very low, and the present prognostic
predictors of SOC are not very sensitive or specific.
Objective: The present study aimed to investigate Microtubule-Actin Cross-Linking Factor 1
(MACF1) expression in SOC tissues (including paraffin-embedded and fresh tissues) and to assess
its expression and significant value in patients with SOC.
Methods: A total of 18 fresh SOC tissues and their paired paratumor tissues were performed with
reverse-transcription quantitative PCR analysis to detect MACF1 mRNA expression. Moreover,
175 paraffin-embedded SOC tissues and 41 paratumor tissues were assessed for MACF1 expression
Results: The mRNA and protein expression of MACF1, both were higher in cancer tissues than
that in paratumor tissues, and the high expression of MACF1 was associated with shorter Recurrence
Free Survival (RFS) and Overall Survival (OS) in patients with SOC. Furthermore, multivariate
regression analysis showed that high MACF1 expression was an independent poor survival predictor
of patients with SOC.
Conclusion: MACF1 is upregulated in SOC, and it may be used as a useful prognostic biomarker