Minocycline and Doxycycline: More Than Antibiotics

(E-pub Ahead of Print)

Author(s): Sher Singh, Deepa Khanna*, Sanjeev Kalra

Journal Name: Current Molecular Pharmacology


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Abstract:

Minocycline and doxycycline both are second-generation tetracycline antibiotic with similar chemical structures and comparable antibacterial spectrum. Minocycline has also emerged as the tetracycline of choice for multidrug-resistant Acinetobacter baumannii infections, although doxycycline has also shown the activity. Minocycline showed promising results in experimental neurology, which was due to its highly lipophilic nature. It is clinically safe and effective adjunct to antipsychotic medications.The objective of the current review is to provide clinical and preclinical, non-antibiotic uses of minocycline as well as doxycycline.Relevant literature covers antibiotic actions but is more specifically concerned with the non-antibiotic biological aspect of the tetracyclines. Non-antibiotic biological effects for both the antibiotics were identified through searching relevant databases including: PubMed, Scopus, and Web of Science up to 2020, using the keywords ‘minocycline and doxycycline’. Anti-inflammatory, anti-oxidant, anti-apoptotic neuroprotective, immunomodulatory and number of other non-antibiotic effects were compiled for minocycline and doxycycline.

Keywords: Minocycline, doxycycline, antibacterial, neuroprotective, anti-cancer, anti-inflammatory

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Article Details

Published on: 10 February, 2021
(E-pub Ahead of Print)
DOI: 10.2174/1874467214666210210122628
Price: $95

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