Coumarins and Quinolones as Effective Multiple Targeted Agents Versus Covid-19: An In silico Study

(E-pub Ahead of Print)

Author(s): Mojgan Nejabat, Razieh Ghodsi, Farzin Hadizadeh*

Journal Name: Medicinal Chemistry


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Abstract:

Background: The Covid-19 virus emerged a few months ago in China and infections rapidly escalated into a pandemic.

Objective: To date, there is no selective antiviral agent for the management of pathologies associated with covid-19 and the need for an effective agent against it is essential.

Method: In this work two home-made databases from synthetic quinolines and coumarins were virtually docked against viral proteases (3CL and PL), human cell surface proteases (TMPRSS2 and furin) and spike proteins (S1 and S2). Chloroquine, a reference drug without a clear mechanism against coronavirus was also docked on mentioned targets and the binding affinities compared with title compounds.

Result: The best compounds of synthetic coumarins and quinolines for each target were determined. All compounds against all targets showed binding affinity between -5.80 to -8.99 kcal/mol in comparison with the FDA-approved drug, Chloroquine, with binding affinity of -5.7 to -7.98 kcal/mol. Two compounds, quinoline-1 and coumarin-24, were found to be effective on three targets – S2, TMPRSS2 and furin – simultaneously, with good predicted affinity between -7.54 to -8.85 kcal/mol. In silico ADME studies also confirmed good oral absorption for them. Furthermore, PASS prediction was calculated and coumarin-24 had higher probable activity (Pa) than probable inactivity (Pi) with acceptable protease inhibitory as well as good antiviral activity against Hepatitis C virus (HCV), Human immunodeficiency virus (HIV) and influenza.

Conclusion: Quinoline-1 and Coumarin-24 have the potential to be used against Covid-19. Hence these agents could be useful in combating covid-19 infection after further in vitro and in vivo studies.

Keywords: Covid-19, Coumarins, Quinolines, Docking, TMPRSS2, furin, protease, Spike, Chloroquine

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Article Details

Published on: 08 February, 2021
(E-pub Ahead of Print)
DOI: 10.2174/1573406417666210208223924
Price: $95

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