Sarcoidosis and Sarcoid Reactions in Endometrial Cancer Cases Masquerading Advanced Stage Malignancy

(E-pub Ahead of Print)

Author(s): Serkan Akis*, Canan Kabaca, Esra Keles, Handan Cetiner, Hatice Akay

Journal Name: Current Women`s Health Reviews

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Background: Sarcoidosis is usually diagnosed by ruling out other granulomatous inflammatory diseases. Rarely, it may be suspected with a pathological examination after surgical intervention for another disease. The sarcoid reaction is noninfectious granulomatous lymphadenitis which can occur at nodes draining a neoplasm. We demonstrated granulomatous lesions masquerading metastasis by Positron Emission Tomography/Computed Tomography (PET/CT) in endometrial cancer. We presented two cases of endometrial cancer with sarcoidosis and sarcoid-like reactions because of their challenging clinical and radiological findings.

Cases: In case 1, there was diffuse granulomatous inflammation (no metastasis) in lymph nodes (n=92) and giant cells containing calcifications (Schaumann bodies). In case 2, PET/CT revealed hypermetabolism with malignancy suspicion in the pelvic lymph nodes (maximum standardized uptake value= 13) and pathological evaluation reported a 4.5 cm tumor within the uterine cavity without any nodal metastasis.

Results: PET/CT has no role in the evaluation of differential diagnosis between granulomatous lymphadenitis and metastatic disease.

Conclusions: Granulomatous lesions might mimic the metastasis of coexisting malignant diseases.

Keywords: Cancer Staging, Endometrial Cancer, Lymph node, Sarcoidosis, Sarcoid Reaction, Schaumann Bodies

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(E-pub Ahead of Print)
DOI: 10.2174/1573404817666210208163237
Price: $95

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